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The Role and Potential Therapeutic Application of Myeloid-Derived Suppressor Cells in Allo- and Autoimmunity
Joint Authors
Zhang, Qi
Xu, Jinhua
Fujino, Masayuki
Li, Xiao-Kang
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that consists of myeloid progenitor cells and immature myeloid cells.
They have been identified as a cell population that may affect the activation of CD4+ and CD8+ T-cells to regulate the immune response negatively, which makes them attractive targets for the treatment of transplantation and autoimmune diseases.
Several studies have suggested the potential suppressive effect of MDSCs on allo- and autoimmune responses.
Conversely, MDSCs have also been found at various stages of differentiation, accumulating during pathological situations, not only during tumor development but also in a variety of inflammatory immune responses, bone marrow transplantation, and some autoimmune diseases.
These findings appear to be contradictory.
In this review, we summarize the roles of MDSCs in different transplantation and autoimmune diseases models as well as the potential to target these cells for therapeutic benefit.
American Psychological Association (APA)
Zhang, Qi& Fujino, Masayuki& Xu, Jinhua& Li, Xiao-Kang. 2015. The Role and Potential Therapeutic Application of Myeloid-Derived Suppressor Cells in Allo- and Autoimmunity. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1072322
Modern Language Association (MLA)
Zhang, Qi…[et al.]. The Role and Potential Therapeutic Application of Myeloid-Derived Suppressor Cells in Allo- and Autoimmunity. Mediators of Inflammation No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1072322
American Medical Association (AMA)
Zhang, Qi& Fujino, Masayuki& Xu, Jinhua& Li, Xiao-Kang. The Role and Potential Therapeutic Application of Myeloid-Derived Suppressor Cells in Allo- and Autoimmunity. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1072322
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072322