Inflammasome in Platelets: Allying Coagulation and Inflammation in Infectious and Sterile Diseases?
Joint Authors
Hottz, Eugenio D.
Monteiro, Ana Paula T.
Bozza, Fernando A.
Bozza, Patricia T.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Platelets are crucial effector cells in hemostasis.
In addition, platelets are increasingly recognized as major inflammatory cells with key roles in innate and adaptive immune responses.
Activated platelets have key thromboinflammatory activities linking coagulation to inflammatory response in a variety of coagulation disorders and vasculopathies.
Recently identified inflammatory activities of platelets include the synthesis of IL-1β from spliced pre-RNA, as well as the presence and assembly of inflammasome which intermediate IL-1β secretion.
Here we review the mechanisms by which platelets activate translation machinery and inflammasome assembly to synthesize and release IL-1β.
The contributions of these processes to protective and pathogenic responses during infectious and inflammatory diseases are discussed.
American Psychological Association (APA)
Hottz, Eugenio D.& Monteiro, Ana Paula T.& Bozza, Fernando A.& Bozza, Patricia T.. 2015. Inflammasome in Platelets: Allying Coagulation and Inflammation in Infectious and Sterile Diseases?. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072331
Modern Language Association (MLA)
Hottz, Eugenio D.…[et al.]. Inflammasome in Platelets: Allying Coagulation and Inflammation in Infectious and Sterile Diseases?. Mediators of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1072331
American Medical Association (AMA)
Hottz, Eugenio D.& Monteiro, Ana Paula T.& Bozza, Fernando A.& Bozza, Patricia T.. Inflammasome in Platelets: Allying Coagulation and Inflammation in Infectious and Sterile Diseases?. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072331
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072331