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The Role of Cytokines, Chemokines, and Growth Factors in the Pathogenesis of Pityriasis Rosea
Joint Authors
Drago, Francesco
Ciccarese, Giulia
Broccolo, Francesco
Ghio, Massimo
Contini, Paola
Thanasi, Hajdhica
Parodi, Aurora
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Pityriasis rosea (PR) is an exanthematous disease related to human herpesvirus- (HHV-) 6/7 reactivation.
The network of mediators involved in recruiting the infiltrating inflammatory cells has never been studied.
Object.
To investigate the levels of serum cytokines, growth factors, and chemokines in PR and healthy controls in order to elucidate the PR pathogenesis.
Materials and Methods.
Interleukin- (IL-) 1, IL-6, IL-17, interferon- (IFN-) γ, tumor necrosis factor- (TNF-) α, vascular endothelial growth factor (VEGF), granulocyte colony stimulating factor (G-CSF), and chemokines, CXCL8 (IL-8) and CXCL10 (IP-10), were measured simultaneously by a multiplex assay in early acute PR patients’ sera and healthy controls.
Subsequently, sera from PR patients were analysed at 3 different times (0, 15, and 30 days).
Results and discussion.
Serum levels of IL-17, IFN-γ, VEGF, and IP-10 resulted to be upregulated in PR patients compared to controls.
IL-17 has a key role in host defense against pathogens stimulating the release of proinflammatory cytokines/chemokines.
IFN-γ has a direct antiviral activity promoting NK cells and virus specific T cells cytotoxicity.
VEGF stimulates vasculogenesis and angiogenesis.
IP-10 can induce chemotaxis, apoptosis, cell growth, and angiogenesis.
Conclusions.
Our findings suggest that these inflammatory mediators may modulate PR pathogenesis in synergistic manner.
American Psychological Association (APA)
Drago, Francesco& Ciccarese, Giulia& Broccolo, Francesco& Ghio, Massimo& Contini, Paola& Thanasi, Hajdhica…[et al.]. 2015. The Role of Cytokines, Chemokines, and Growth Factors in the Pathogenesis of Pityriasis Rosea. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1072352
Modern Language Association (MLA)
Drago, Francesco…[et al.]. The Role of Cytokines, Chemokines, and Growth Factors in the Pathogenesis of Pityriasis Rosea. Mediators of Inflammation No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1072352
American Medical Association (AMA)
Drago, Francesco& Ciccarese, Giulia& Broccolo, Francesco& Ghio, Massimo& Contini, Paola& Thanasi, Hajdhica…[et al.]. The Role of Cytokines, Chemokines, and Growth Factors in the Pathogenesis of Pityriasis Rosea. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1072352
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072352