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Lipid Peroxidation-Mediated Inflammation Promotes Cell Apoptosis through Activation of NF-κB Pathway in Rheumatoid Arthritis Synovial Cells
Joint Authors
Yin, Geng
Yang, Min
Cen, Xiao-min
Xie, Qi-bing
Wang, Ying
Liang, Yan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of multiple joints.
The central pathogenesis of RA is the proliferation of synovial fibroblasts in response to inflammatory cytokines.
However, some of the targeted therapies for inflammation reactions do not display significant clinical improvement after initiation of therapy.
Thus, the relationship between inflammatory responses and RA therapy is still incompletely understood.
In the present study, we proposed to determine whether enhanced inflammations may lead to cell apoptosis in rheumatoid arthritis synoviocytes.
Our results indicated that products of lipid peroxidations, 4-HNE, may induce synovial intrinsic inflammations by activating NF-κB pathways and it may lead to cell apoptosis.
Pharmacological inhibition of NF-κB activation may reduce the 4-HNE mediated inflammation responses and subsequent cell apoptosis.
Our results may help to clarify the role of inflammations on RA development and imply that blocking NF-κB activation may be partly beneficial for human RA therapy.
These findings might provide a mechanism-based rationale for developing new strategy to RA clinical therapy.
American Psychological Association (APA)
Yin, Geng& Wang, Ying& Cen, Xiao-min& Yang, Min& Liang, Yan& Xie, Qi-bing. 2015. Lipid Peroxidation-Mediated Inflammation Promotes Cell Apoptosis through Activation of NF-κB Pathway in Rheumatoid Arthritis Synovial Cells. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072366
Modern Language Association (MLA)
Yin, Geng…[et al.]. Lipid Peroxidation-Mediated Inflammation Promotes Cell Apoptosis through Activation of NF-κB Pathway in Rheumatoid Arthritis Synovial Cells. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072366
American Medical Association (AMA)
Yin, Geng& Wang, Ying& Cen, Xiao-min& Yang, Min& Liang, Yan& Xie, Qi-bing. Lipid Peroxidation-Mediated Inflammation Promotes Cell Apoptosis through Activation of NF-κB Pathway in Rheumatoid Arthritis Synovial Cells. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072366
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072366