HLA Haplotypes and Genotypes Frequencies in Brazilian Chronic Periodontitis Patients
Joint Authors
Visentainer, Jeane Eliete Laguila
Ayo, Christiane Maria
Sell, Ana Maria
Sippert, Emília Ângela
Marques, Silvia Barbosa Dutra
Silva, C.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Human leukocyte antigens (HLA) have a pivotal role in immune response and may be involved in antigen recognition of periodontal pathogens.
However, the associations of HLA with chronic periodontitis (CP) have not been previously studied in the Brazilian population.
In an attempt to clarify the issue of genetic predisposition to CP, we examined the distribution of HLA alleles, genotypes, and haplotypes in patients from Southern Brazil.
One hundred and eight CP patients and 151 healthy and unrelated controls with age-, gender-, and ethnicity-matched were HLA investigated by polymerase chain reaction with sequence specific oligonucleotides.
To exclude smoking as a predisposing factor, statistical analyses were performed in the total sample and in nonsmoking individuals.
The significant results showed a positive association of the A∗02/HLA-B∗40 haplotype with CP (total samples: 4.2% versus 0%, P c = 0.03; nonsmokers: 4.3% versus 0%, P c = 0.23) and a lower frequency of HLA-B∗15/HLA-DRB1∗11 haplotype in CP compared to controls (total samples: 0.0% versus 4.3%, P c = 0.04; nonsmokers: 0 versus 5.1%, P c = 1.0).
In conclusion, the HLA-A∗02/B∗40 haplotype may contribute to the development of CP, while HLA-B∗15/DRB1∗11 haplotype might indicate resistance to disease among Brazilians.
American Psychological Association (APA)
Sippert, Emília Ângela& Silva, C.& Ayo, Christiane Maria& Marques, Silvia Barbosa Dutra& Visentainer, Jeane Eliete Laguila& Sell, Ana Maria. 2015. HLA Haplotypes and Genotypes Frequencies in Brazilian Chronic Periodontitis Patients. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072375
Modern Language Association (MLA)
Sippert, Emília Ângela…[et al.]. HLA Haplotypes and Genotypes Frequencies in Brazilian Chronic Periodontitis Patients. Mediators of Inflammation No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1072375
American Medical Association (AMA)
Sippert, Emília Ângela& Silva, C.& Ayo, Christiane Maria& Marques, Silvia Barbosa Dutra& Visentainer, Jeane Eliete Laguila& Sell, Ana Maria. HLA Haplotypes and Genotypes Frequencies in Brazilian Chronic Periodontitis Patients. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072375
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072375