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Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale
Joint Authors
Rungatscher, Alessio
Tessari, Maddalena
Stranieri, Chiara
Solani, Erika
Linardi, Daniele
Milani, Elisabetta
Montresor, Alessio
Merigo, Flavia
Salvetti, Beatrice
Menon, Tiziano
Faggian, Giuseppe
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In order to assess mechanisms underlying inflammatory activation during extracorporeal circulation (ECC), several small animal models of ECC have been proposed recently.
The majority of them are based on home-made, nonstandardized, and hardly reproducible oxygenators.
The present study has generated fundamental information on the role of oxygenator of ECC in activating inflammatory signaling pathways on leukocytes, leading to systemic inflammatory response, and organ dysfunction.
The present results suggest that experimental animal models of ECC used in translational research on inflammatory response should be based on standardized, reproducible oxygenators with clinical characteristics.
American Psychological Association (APA)
Rungatscher, Alessio& Tessari, Maddalena& Stranieri, Chiara& Solani, Erika& Linardi, Daniele& Milani, Elisabetta…[et al.]. 2015. Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072378
Modern Language Association (MLA)
Rungatscher, Alessio…[et al.]. Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale. Mediators of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1072378
American Medical Association (AMA)
Rungatscher, Alessio& Tessari, Maddalena& Stranieri, Chiara& Solani, Erika& Linardi, Daniele& Milani, Elisabetta…[et al.]. Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072378
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072378