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C57BL6 and AJ Mice Have Different Inflammatory Response and Liver Lipid Profile in Experimental Alcoholic Liver Disease
Joint Authors
Bavia, Lorena
Castro, Íris Arantes de
Isaac, Lourdes
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Alcoholic liver disease (ALD) is an important worldwide public health issue characterized by liver steatosis, inflammation, necrosis, and apoptosis of hepatocytes with eventual development of fibrosis and cirrhosis.
Comparison of murine models with different inflammatory responses for ALD is important for an evaluation of the importance of genetic background in the interpretation of ethanol-induced phenotypes.
Here, we investigated the role of inflammation and genetic background for the establishment of ALD using two different mouse strains: C57BL/6 (B6) and A/J.
B6 and A/J mice were treated with a high fat diet containing ethanol (HFDE) and compared to the controls for 10 weeks.
Hepatomegaly and steatohepatitis were similar in B6 and A/J mice, but only A/J mice were resistant to weight gain.
On the other hand, HFDE-fed B6 accumulated more triglycerides (TG) and cholesterol and presented more intense cellular infiltrate in the liver when compared to HFDM-fed mice.
Liver inflammatory environment was distinct in these two mouse strains.
While HFDE-fed B6 produced more liver IL-12, A/J mice increased the TNF-α production.
We concluded that mouse genetic background could dictate the intensity of the HFDE-induced liver injury.
American Psychological Association (APA)
Bavia, Lorena& Castro, Íris Arantes de& Isaac, Lourdes. 2015. C57BL6 and AJ Mice Have Different Inflammatory Response and Liver Lipid Profile in Experimental Alcoholic Liver Disease. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072382
Modern Language Association (MLA)
Bavia, Lorena…[et al.]. C57BL6 and AJ Mice Have Different Inflammatory Response and Liver Lipid Profile in Experimental Alcoholic Liver Disease. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072382
American Medical Association (AMA)
Bavia, Lorena& Castro, Íris Arantes de& Isaac, Lourdes. C57BL6 and AJ Mice Have Different Inflammatory Response and Liver Lipid Profile in Experimental Alcoholic Liver Disease. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072382
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072382