Vitamin D Potentiates the Inhibitory Effect of MicroRNA-130a in Hepatitis C Virus Replication Independent of Type I Interferon Signaling Pathway
Joint Authors
Chen, Limin
Duan, Xiaoqiong
Guan, Yujuan
Li, Yujia
Chen, Shan
Li, Shilin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Calcitriol, the bioactive metabolite of vitamin D, was reported to inhibit HCV production in a synergistic fashion with interferon, a treatment in vitro.
Our previous study established that miR-130a inhibits HCV replication by restoring the host innate immune response.
We aimed to determine whether there is additive inhibitory effect of calcitriol and miR-130a on HCV replication.
Here we showed that calcitriol potentiates the anti-HCV effect of miR-130a in both Con1b replicon and J6/JFH1 culture systems.
Intriguingly, this potentiating effect of calcitriol on miR-130a was not through upregulating the expression of cellular miR-130a or through increasing the miR-130a-mediated IFNα/β production.
All these findings may contribute to the development of novel anti-HCV therapeutic strategies although the antiviral mechanism needs to be further investigated.
American Psychological Association (APA)
Duan, Xiaoqiong& Guan, Yujuan& Li, Yujia& Chen, Shan& Li, Shilin& Chen, Limin. 2015. Vitamin D Potentiates the Inhibitory Effect of MicroRNA-130a in Hepatitis C Virus Replication Independent of Type I Interferon Signaling Pathway. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1072392
Modern Language Association (MLA)
Duan, Xiaoqiong…[et al.]. Vitamin D Potentiates the Inhibitory Effect of MicroRNA-130a in Hepatitis C Virus Replication Independent of Type I Interferon Signaling Pathway. Mediators of Inflammation No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1072392
American Medical Association (AMA)
Duan, Xiaoqiong& Guan, Yujuan& Li, Yujia& Chen, Shan& Li, Shilin& Chen, Limin. Vitamin D Potentiates the Inhibitory Effect of MicroRNA-130a in Hepatitis C Virus Replication Independent of Type I Interferon Signaling Pathway. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1072392
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072392