Role of the Immunogenic and Tolerogenic Subsets of Dendritic Cells in Multiple Sclerosis
Joint Authors
Zhang, Hong-Liang
Zhu, Jie
Jin, Tao
Wu, Xiujuan
Xie, Zhong-Xiang
Ma, Di-Hui
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-29
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Multiple sclerosis (MS) is an immune-mediated disorder in the central nervous system (CNS) characterized by inflammation and demyelination as well as axonal and neuronal degeneration.
So far effective therapies to reverse the disease are still lacking; most therapeutic drugs can only ameliorate the symptoms or reduce the frequency of relapse.
Dendritic cells (DCs) are professional antigen presenting cells (APCs) that are key players in both mediating immune responses and inducing immune tolerance.
Increasing evidence indicates that DCs contribute to the pathogenesis of MS and might provide an avenue for therapeutic intervention.
Here, we summarize the immunogenic and tolerogenic roles of DCs in MS and review medicinal drugs that may affect functions of DCs and have been applied in clinic for MS treatment.
We also describe potential therapeutic molecules that can target DCs by inducing anti-inflammatory cytokines and inhibiting proinflammatory cytokines in MS.
American Psychological Association (APA)
Xie, Zhong-Xiang& Zhang, Hong-Liang& Wu, Xiujuan& Zhu, Jie& Ma, Di-Hui& Jin, Tao. 2015. Role of the Immunogenic and Tolerogenic Subsets of Dendritic Cells in Multiple Sclerosis. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-20.
https://search.emarefa.net/detail/BIM-1072397
Modern Language Association (MLA)
Xie, Zhong-Xiang…[et al.]. Role of the Immunogenic and Tolerogenic Subsets of Dendritic Cells in Multiple Sclerosis. Mediators of Inflammation No. 2015 (2015), pp.1-20.
https://search.emarefa.net/detail/BIM-1072397
American Medical Association (AMA)
Xie, Zhong-Xiang& Zhang, Hong-Liang& Wu, Xiujuan& Zhu, Jie& Ma, Di-Hui& Jin, Tao. Role of the Immunogenic and Tolerogenic Subsets of Dendritic Cells in Multiple Sclerosis. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-20.
https://search.emarefa.net/detail/BIM-1072397
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072397