5′-Adenosine Monophosphate-Induced Hypothermia Attenuates Brain IschemiaReperfusion Injury in a Rat Model by Inhibiting the Inflammatory Response
Joint Authors
Qiu, Yongming
Miao, Yi-Feng
Wu, Hui
Yang, Shao-Feng
Dai, Jiong
Tao, Zhen-Yi
Zhang, Xiao-Hua
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hypothermia treatment is a promising therapeutic strategy for brain injury.
We previously demonstrated that 5′-adenosine monophosphate (5′-AMP), a ribonucleic acid nucleotide, produces reversible deep hypothermia in rats when the ambient temperature is appropriately controlled.
Thus, we hypothesized that 5′-AMP-induced hypothermia (AIH) may attenuate brain ischemia/reperfusion injury.
Transient cerebral ischemia was induced by using the middle cerebral artery occlusion (MCAO) model in rats.
Rats that underwent AIH treatment exhibited a significant reduction in neutrophil elastase infiltration into neuronal cells and matrix metalloproteinase 9 (MMP-9), interleukin-1 receptor (IL-1R), tumor necrosis factor receptor (TNFR), and Toll-like receptor (TLR) protein expression in the infarcted area compared to euthermic controls.
AIH treatment also decreased the number of terminal deoxynucleotidyl transferase dUTP nick end labeling- (TUNEL-) positive neuronal cells.
The overall infarct volume was significantly smaller in AIH-treated rats, and neurological function was improved.
By contrast, rats with ischemic brain injury that were administered 5′-AMP without inducing hypothermia had ischemia/reperfusion injuries similar to those in euthermic controls.
Thus, the neuroprotective effects of AIH were primarily related to hypothermia.
American Psychological Association (APA)
Miao, Yi-Feng& Wu, Hui& Yang, Shao-Feng& Dai, Jiong& Qiu, Yongming& Tao, Zhen-Yi…[et al.]. 2015. 5′-Adenosine Monophosphate-Induced Hypothermia Attenuates Brain IschemiaReperfusion Injury in a Rat Model by Inhibiting the Inflammatory Response. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072402
Modern Language Association (MLA)
Miao, Yi-Feng…[et al.]. 5′-Adenosine Monophosphate-Induced Hypothermia Attenuates Brain IschemiaReperfusion Injury in a Rat Model by Inhibiting the Inflammatory Response. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072402
American Medical Association (AMA)
Miao, Yi-Feng& Wu, Hui& Yang, Shao-Feng& Dai, Jiong& Qiu, Yongming& Tao, Zhen-Yi…[et al.]. 5′-Adenosine Monophosphate-Induced Hypothermia Attenuates Brain IschemiaReperfusion Injury in a Rat Model by Inhibiting the Inflammatory Response. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072402