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MicroRNA Dysregulation in Cystic Fibrosis
Joint Authors
McKiernan, Paul J.
Greene, Catherine M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The cystic fibrosis lung is a complex milieu comprising multiple factors that coordinate its physiology.
MicroRNAs are regulatory factors involved in most biological processes and it is becoming increasingly clear that they play a key role in the development and manifestations of CF lung disease.
These small noncoding RNAs act posttranscriptionally to inhibit protein production.
Their involvement in the pathogenesis of CF lung disease stems from the fact that their expression is altered in vivo in the CF lung due to intrinsic and extrinsic factors; to date defective chloride ion conductance, endoplasmic reticulum stress, inflammation, and infection have been implicated in altering endogenous miRNA expression in this setting.
Here, the current state-of-the-art and biological consequences of altered microRNA expression in cystic fibrosis are reviewed.
American Psychological Association (APA)
McKiernan, Paul J.& Greene, Catherine M.. 2015. MicroRNA Dysregulation in Cystic Fibrosis. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072407
Modern Language Association (MLA)
McKiernan, Paul J.& Greene, Catherine M.. MicroRNA Dysregulation in Cystic Fibrosis. Mediators of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1072407
American Medical Association (AMA)
McKiernan, Paul J.& Greene, Catherine M.. MicroRNA Dysregulation in Cystic Fibrosis. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072407
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072407