Excessive Daytime Sleepiness Is Associated with Changes in Salivary Inflammatory Genes Transcripts
Joint Authors
Thimgan, Matthew S.
Toedebusch, Cristina
McLeland, Jennifer
Duntley, Stephen P.
Shaw, Paul J.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Excessive daytime sleepiness (EDS) is a ubiquitous problem that affects public health and safety.
A test that can reliably identify individuals that suffer from EDS is needed.
In contrast to other methods, salivary biomarkers are an objective, inexpensive, and noninvasive method to identify individuals with inadequate sleep.
Although we have previously shown that inflammatory genes are elevated in saliva samples taken from sleep deprived individuals, it is unclear if inflammatory genes will be elevated in clinical populations with EDS.
In this study, salivary samples from individuals with sleep apnea were evaluated using the Taqman low density inflammation array.
Transcript levels for 3 genes, including prostaglandin-endoperoxide synthase 2 (PTGS2), were elevated in patients with sleep apnea.
Interestingly, PTGS2 was also elevated in patients with EDS but who did not have sleep apnea.
These data demonstrate the feasibility of using salivary transcript levels to identify individuals that self-report excessive daytime sleepiness.
American Psychological Association (APA)
Thimgan, Matthew S.& Toedebusch, Cristina& McLeland, Jennifer& Duntley, Stephen P.& Shaw, Paul J.. 2015. Excessive Daytime Sleepiness Is Associated with Changes in Salivary Inflammatory Genes Transcripts. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072414
Modern Language Association (MLA)
Thimgan, Matthew S.…[et al.]. Excessive Daytime Sleepiness Is Associated with Changes in Salivary Inflammatory Genes Transcripts. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072414
American Medical Association (AMA)
Thimgan, Matthew S.& Toedebusch, Cristina& McLeland, Jennifer& Duntley, Stephen P.& Shaw, Paul J.. Excessive Daytime Sleepiness Is Associated with Changes in Salivary Inflammatory Genes Transcripts. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072414
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072414