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Chemerin15-Ameliorated Cardiac Ischemia-Reperfusion Injury Is Associated with the Induction of Alternatively Activated Macrophages
Joint Authors
Wu, Bang-wei
Yu, Kunwu
Chang, Chao
Zeng, Qiutang
Xin, Shuanli
Liu, Jixiang
Zhou, Yujie
Ji, Qing-wei
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Chemerin15 (C15), an endogenous anti-inflammatory component, inhibits the activity of neutrophils and macrophages through G protein-coupled receptor ChemR23; however, its role as well as functional mechanism in mouse myocardial ischemia/reperfusion (I/R) injury remains unknown.
Methods.
Sham or I/R operations were performed on C57BL/6J mice.
The I/R mice received an injection of C15 immediately before reperfusion.
Serum troponin T levels, infarct size, cardiomyocyte apoptosis, reactive oxygen species (ROS) production, and infiltration of neutrophils were assessed 24 h after reperfusion, while the macrophage phenotypes, macrophage infiltration, and inflammatory cytokine levels were assessed 48 h after reperfusion.
Results.
Compared with the control group, the C15-treated mice showed an obvious amelioration of I/R injury and displayed less ROS, accompanied by reduced neutrophil recruitment.
C15 decreased the tumor necrosis factor- (TNF-) α and interleukin- (IL-) 6 levels and increased the IL-10 levels in the serum of the I/R mice, which suggested a suppressed inflammatory response that could be related to elevated alternatively activated M2 macrophages with characteristic skewed expression of M2 markers and inhibition of classically activated M1 marker expression.
Conclusion.
C15 may induce alternatively activated M2 macrophage polarization and suppress the inflammatory response to protect against myocardial I/R injury in mice.
American Psychological Association (APA)
Chang, Chao& Ji, Qing-wei& Wu, Bang-wei& Yu, Kunwu& Zeng, Qiutang& Xin, Shuanli…[et al.]. 2015. Chemerin15-Ameliorated Cardiac Ischemia-Reperfusion Injury Is Associated with the Induction of Alternatively Activated Macrophages. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072423
Modern Language Association (MLA)
Chang, Chao…[et al.]. Chemerin15-Ameliorated Cardiac Ischemia-Reperfusion Injury Is Associated with the Induction of Alternatively Activated Macrophages. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072423
American Medical Association (AMA)
Chang, Chao& Ji, Qing-wei& Wu, Bang-wei& Yu, Kunwu& Zeng, Qiutang& Xin, Shuanli…[et al.]. Chemerin15-Ameliorated Cardiac Ischemia-Reperfusion Injury Is Associated with the Induction of Alternatively Activated Macrophages. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072423
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072423