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An Inflammatory Polymorphisms Risk Scoring System for the Differentiation of Ischemic Stroke Subtypes
Joint Authors
Muiño, Elena
Krupinski, Jurek
Carrera, Caty
Gallego-Fabrega, Cristina
Fernández-Cadenas, Israel
Montaner, J.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Inflammation has been associated with atherothrombotic stroke and recently with cardioembolic stroke.
Different genetic risk factors have been specifically associated with the subtypes of ischemic stroke (cardioembolic, atherothrombotic, and lacunar).
However, there are no studies that have generated genetic risk scores for the different subtypes of ischemic stroke using polymorphisms associated with inflammation.
Methods.
We have analyzed 68 polymorphisms of 30 inflammatory mediator genes in 2,685 subjects: 1,987 stroke cases and 698 controls.
We generated a genetic scoring system with the most significant polymorphisms weighted by the odds ratio of every polymorphism and taken into consideration the stroke subtype.
Results.
Three polymorphisms, rs1205 (CRP gene), rs1800779, and rs2257073 (NOS3 gene), were associated with cardioembolic stroke (p value <0.05).
The score generated was only associated with the cardioembolic stroke subtype (p value: 0.001) and was replicated in an independent cohort (p value: 0.017).
The subjects with the highest score presented a cardioembolic stroke in 92.2% of the cases (p value: 0.002).
Conclusion.
The genetics of inflammatory markers is more closely associated with cardioembolic strokes than with atherothrombotic or lacunar strokes.
The genetic risk scoring system could be useful in the prediction and differentiation of ischemic stroke; however, it might be specific to particular ischemic stroke subtypes.
American Psychological Association (APA)
Muiño, Elena& Krupinski, Jurek& Carrera, Caty& Gallego-Fabrega, Cristina& Montaner, J.& Fernández-Cadenas, Israel. 2015. An Inflammatory Polymorphisms Risk Scoring System for the Differentiation of Ischemic Stroke Subtypes. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072430
Modern Language Association (MLA)
Muiño, Elena…[et al.]. An Inflammatory Polymorphisms Risk Scoring System for the Differentiation of Ischemic Stroke Subtypes. Mediators of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1072430
American Medical Association (AMA)
Muiño, Elena& Krupinski, Jurek& Carrera, Caty& Gallego-Fabrega, Cristina& Montaner, J.& Fernández-Cadenas, Israel. An Inflammatory Polymorphisms Risk Scoring System for the Differentiation of Ischemic Stroke Subtypes. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072430
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072430