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Hypoxia Inducible Factor Pathway and Physiological Adaptation: A Cell Survival Pathway?
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Oxygen homeostasis reflects the constant body requirement to generate energy.
Hypoxia (0.1–1% O2), physioxia or physoxia (∼1–13%), and normoxia (∼20%) are terms used to define oxygen concentration in the cellular environment.
A decrease in oxygen (hypoxia) or excess oxygen (hyperoxia) could be deleterious for cellular adaptation and survival.
Hypoxia can occur under both physiological (e.g., exercise, embryonic development, underwater diving, or high altitude) and pathological conditions (e.g., inflammation, solid tumor formation, lung disease, or myocardial infarction).
Hypoxia plays a key role in the pathophysiology of heart disease, cancers, stroke, and other causes of mortality.
Hypoxia inducible factor(s) (HIFs) are key oxygen sensors that mediate the ability of the cell to cope with decreased oxygen tension.
These transcription factors regulate cellular adaptation to hypoxia and protect cells by responding acutely and inducing production of endogenous metabolites and proteins to promptly regulate metabolic pathways.
Here, we review the role of the HIF pathway as a metabolic adaptation pathway and how this pathway plays a role in cell survival.
We emphasize the roles of the HIF pathway in physiological adaptation, cell death, pH regulation, and adaptation during exercise.
American Psychological Association (APA)
Kumar, Hemant& Choi, Dong-Kug. 2015. Hypoxia Inducible Factor Pathway and Physiological Adaptation: A Cell Survival Pathway?. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072434
Modern Language Association (MLA)
Kumar, Hemant& Choi, Dong-Kug. Hypoxia Inducible Factor Pathway and Physiological Adaptation: A Cell Survival Pathway?. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072434
American Medical Association (AMA)
Kumar, Hemant& Choi, Dong-Kug. Hypoxia Inducible Factor Pathway and Physiological Adaptation: A Cell Survival Pathway?. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072434