Adaptive Immunity and Antigen-Specific Activation in Obesity-Associated Insulin Resistance
Joint Authors
Chng, Melissa Hui Yen
Alonso, Michael N.
Barnes, Sarah E.
Nguyen, Khoa D.
Engleman, Edgar G.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-04
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Type 2 diabetes mellitus (T2D) is a metabolic disease that is strongly tied to obesity and often preceded by insulin resistance (IR).
It has been established that chronic inflammation of hypertrophic adipose tissue depots in obese individuals leads to obesity-associated IR and is mediated by cells of the innate immune system, particularly macrophages.
More recently, cells of the adaptive immune system, B and T lymphocytes, have also emerged as important regulators of glucose homeostasis, raising the intriguing possibility that antigen-driven immune responses play a role in disease.
In this review, we critically evaluate the roles that various B and T cell subsets play in IR, and then we examine the data suggesting that antigen-driven mechanisms, such as antigen presentation and costimulation, may drive the activity of these lymphocytes.
American Psychological Association (APA)
Chng, Melissa Hui Yen& Alonso, Michael N.& Barnes, Sarah E.& Nguyen, Khoa D.& Engleman, Edgar G.. 2015. Adaptive Immunity and Antigen-Specific Activation in Obesity-Associated Insulin Resistance. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1072437
Modern Language Association (MLA)
Chng, Melissa Hui Yen…[et al.]. Adaptive Immunity and Antigen-Specific Activation in Obesity-Associated Insulin Resistance. Mediators of Inflammation No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1072437
American Medical Association (AMA)
Chng, Melissa Hui Yen& Alonso, Michael N.& Barnes, Sarah E.& Nguyen, Khoa D.& Engleman, Edgar G.. Adaptive Immunity and Antigen-Specific Activation in Obesity-Associated Insulin Resistance. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1072437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072437