Moderate Exercise Training Attenuates the Severity of Experimental Rodent Colitis: The Importance of Crosstalk between Adipose Tissue and Skeletal Muscles
Joint Authors
Magierowski, Marcin
Jasnos, Katarzyna
Krzysiek-Maczka, Gracjana
Urbanczyk, Katarzyna
Ptak-Belowska, Agata
Mach, Tomasz
Mazur-Bialy, Agnieszka
Bilski, Jan
Zwolińska-Wcisło, Małgorzata
Brzozowski, Bartosz
Brzozowski, Tomasz
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Although progress has been recently made in understanding of inflammatory bowel diseases (IBD), their etiology is unknown apart from several factors from adipose tissue and skeletal muscles such as cytokines, adipokines, and myokines were implicated in the pathogenesis of ulcerative colitis.
We studied the effect high-fat diet (HFD; cholesterol up to 70%), low-fat diet (LFD; cholesterol up to 10%), and the normal diet (total fat up to 5%) in rats with TNBS colitis forced to treadmill running exercise (5 days/week) for 6 weeks.
In nonexercising HFD rats, the area of colonic damage, colonic tissue weight, the plasma IL-1β, TNF-α, TWEAK, and leptin levels, and the expression of IL-1β-, TNF-α-, and Hif1α mRNAs were significantly increased and a significant fall in plasma adiponectin and irisin levels was observed as compared to LFD rats.
In HFD animals, the exercise significantly accelerated the healing of colitis, raised the plasma levels of IL-6 and irisin, downregulated the expression of IL-1β, TNF-α, and Hif1α, and significantly decreased the plasma IL-1β, TNF α, TWEAK, and leptin levels.
We conclude that HFD delays the healing of colitis in trained rats via decrease in CBF and plasma IL-1β, TNF-α, TWEAK, and leptin levels and the release of protective irisin.
American Psychological Association (APA)
Bilski, Jan& Mazur-Bialy, Agnieszka& Brzozowski, Bartosz& Magierowski, Marcin& Jasnos, Katarzyna& Krzysiek-Maczka, Gracjana…[et al.]. 2015. Moderate Exercise Training Attenuates the Severity of Experimental Rodent Colitis: The Importance of Crosstalk between Adipose Tissue and Skeletal Muscles. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072446
Modern Language Association (MLA)
Bilski, Jan…[et al.]. Moderate Exercise Training Attenuates the Severity of Experimental Rodent Colitis: The Importance of Crosstalk between Adipose Tissue and Skeletal Muscles. Mediators of Inflammation No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1072446
American Medical Association (AMA)
Bilski, Jan& Mazur-Bialy, Agnieszka& Brzozowski, Bartosz& Magierowski, Marcin& Jasnos, Katarzyna& Krzysiek-Maczka, Gracjana…[et al.]. Moderate Exercise Training Attenuates the Severity of Experimental Rodent Colitis: The Importance of Crosstalk between Adipose Tissue and Skeletal Muscles. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072446
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072446