The Effects of Paracoccidioides brasiliensis Infection on GM-CSF- and M-CSF-Induced Mouse Bone Marrow-Derived Macrophage from Resistant and Susceptible Mice Strains
Joint Authors
de Souza Silva, Calliandra
Tavares, Aldo Henrique
Sousa Jeronimo, Marcio
Soares de Lima, Yasmin
da Silveira Derengowski, Lorena
Lorenzetti Bocca, Anamélia
Silva-Pereira, Ildinete
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-12
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Considering the importance of macrophages as the first line of defense against fungal infection and the different roles played by the two M1- and M2-like polarized macrophages, we decided to evaluate the effects of Paracoccidioides brasiliensis infection on GM-CSF- and M-CSF-induced bone marrow-derived macrophages (BMM) from the A/J and B10.A mouse strains, an established model of resistance/susceptibility to PCM, respectively.
Upon differentiation, the generated GM- or M-BMMs were characterized by morphological analyses, gene expression profiles, and cytokines production.
Our main results demonstrate that GM-BMMs derived from A/J and B.10 produced high levels of pro- and anti-inflammatory cytokines that may contribute to generate an unbalanced early immune response.
In accordance with the literature, the B10.A susceptible mice lineage has an innate tendency to polarize into M1-like phenotype, whereas the opposite phenotype occurs in A/J resistance mice.
In this context, our data support that susceptibility and resistance are strongly correlated with M1 and M2 polarization, respectively.
American Psychological Association (APA)
de Souza Silva, Calliandra& Tavares, Aldo Henrique& Sousa Jeronimo, Marcio& Soares de Lima, Yasmin& da Silveira Derengowski, Lorena& Lorenzetti Bocca, Anamélia…[et al.]. 2015. The Effects of Paracoccidioides brasiliensis Infection on GM-CSF- and M-CSF-Induced Mouse Bone Marrow-Derived Macrophage from Resistant and Susceptible Mice Strains. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1072447
Modern Language Association (MLA)
de Souza Silva, Calliandra…[et al.]. The Effects of Paracoccidioides brasiliensis Infection on GM-CSF- and M-CSF-Induced Mouse Bone Marrow-Derived Macrophage from Resistant and Susceptible Mice Strains. Mediators of Inflammation No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1072447
American Medical Association (AMA)
de Souza Silva, Calliandra& Tavares, Aldo Henrique& Sousa Jeronimo, Marcio& Soares de Lima, Yasmin& da Silveira Derengowski, Lorena& Lorenzetti Bocca, Anamélia…[et al.]. The Effects of Paracoccidioides brasiliensis Infection on GM-CSF- and M-CSF-Induced Mouse Bone Marrow-Derived Macrophage from Resistant and Susceptible Mice Strains. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1072447
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072447