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Toll-Like Receptor-4 Mediated Inflammation Is Involved in the Cardiometabolic Alterations Induced by Intermittent Hypoxia
Joint Authors
Lévy, Patrick A.
Poulain, Laureline
Dematteis, Maurice
Arnaud, Claire
Richard, Vincent
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
Intermittent hypoxia (IH) is a major component of sleep apnea syndrome as its cardiometabolic complications have been mainly attributed to IH.
The pathophysiology is still poorly understood but there are some similarities with the obesity-associated cardiometabolic complications.
As the latter results from inflammation involving toll-like receptor-4 (TLR4) signaling, we assessed this pathway in the cardiometabolic consequences of IH.
Methods.
Lean adult male TLR4-deficient (TLR4−/−) mice and their controls (C57BL/6 mice) were exposed to either IH (FiO2 21-5%, 1 min cycle, 8 h/day) or air (normoxic mice) for 4 weeks.
Animals were assessed at 1-week exposure for insulin tolerance test and after 4-week exposure for morphological and inflammatory changes of the epididymal fat and thoracic aorta.
Results.
IH induced insulin resistance, morphological and inflammatory changes of the epididymal fat (smaller pads and adipocytes, higher release of TNF-α and IL-6) and aorta (larger intima-media thickness and higher NFκB-p50 activity).
All these alterations were prevented by TLR4 deletion.
Conclusion.
IH induces metabolic and vascular alterations that involve TLR4 mediated inflammation.
These results confirm the important role of inflammation in the cardiometabolic consequences of IH and suggest that targeting TLR4/NFκB pathway could represent a further therapeutic option for sleep apnea patients.
American Psychological Association (APA)
Poulain, Laureline& Richard, Vincent& Lévy, Patrick A.& Dematteis, Maurice& Arnaud, Claire. 2015. Toll-Like Receptor-4 Mediated Inflammation Is Involved in the Cardiometabolic Alterations Induced by Intermittent Hypoxia. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072458
Modern Language Association (MLA)
Poulain, Laureline…[et al.]. Toll-Like Receptor-4 Mediated Inflammation Is Involved in the Cardiometabolic Alterations Induced by Intermittent Hypoxia. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072458
American Medical Association (AMA)
Poulain, Laureline& Richard, Vincent& Lévy, Patrick A.& Dematteis, Maurice& Arnaud, Claire. Toll-Like Receptor-4 Mediated Inflammation Is Involved in the Cardiometabolic Alterations Induced by Intermittent Hypoxia. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072458
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072458