Macrophage Migration Inhibitory Factor Interacting with Th17 Cells May Be Involved in the Pathogenesis of Autoimmune Damage in Hashimoto’s Thyroiditis
Joint Authors
Xue, Haibo
Yang, Yuhua
Zhang, Ying
Song, Shoujun
Zhang, Li
Ma, Lei
Yang, Tingting
Liu, Huan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
To explore the possible role of MIF and Th17 cells in the thyroid-specific autoimmune damage of Hashimoto’s thyroiditis (HT).
Material and Methods.
We enrolled 40 HT patients and 30 healthy controls and divided HT patients into euthyroid subset ( n = 22 ) and subclinical or overt hypothyroidism subset ( n = 18 ).
The percentages of Th17 cells and expressions of MIF, interleukin 17A (IL-17A) mRNA in PBMCs, as well as serum concentrations of MIF, and IL-17A, and thyroid functions, and thyroid-specific autoantibodies (TPOAb, TgAb) were detected by flow cytometry, real-time RT-PCR, ELISA, and ECLIA in all subjects.
Results.
MIF mRNA, IL-17A mRNA expressions and Th17 cells percentages, serum MIF, and IL-17A protein levels were all significantly higher in HT patients, even in euthyroid subgroup.
Additionally, the differences became more obvious in dysfunction subgroup.
Importantly, both MIF levels and Th17 cells percentage were positively correlated with serum TPOAb, TgAb, and thyrotropin (TSH) levels in HT patients.
Conclusions.
These data suggest that MIF and Th17 cells increased dynamically and positively correlated with the markers of thyroid autoimmune damage, which indicated that interaction between MIF and Th17 cells may participate in the pathogenesis and development of thyroid-specific autoimmunity in HT.
American Psychological Association (APA)
Xue, Haibo& Yang, Yuhua& Zhang, Ying& Song, Shoujun& Zhang, Li& Ma, Lei…[et al.]. 2015. Macrophage Migration Inhibitory Factor Interacting with Th17 Cells May Be Involved in the Pathogenesis of Autoimmune Damage in Hashimoto’s Thyroiditis. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072461
Modern Language Association (MLA)
Xue, Haibo…[et al.]. Macrophage Migration Inhibitory Factor Interacting with Th17 Cells May Be Involved in the Pathogenesis of Autoimmune Damage in Hashimoto’s Thyroiditis. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072461
American Medical Association (AMA)
Xue, Haibo& Yang, Yuhua& Zhang, Ying& Song, Shoujun& Zhang, Li& Ma, Lei…[et al.]. Macrophage Migration Inhibitory Factor Interacting with Th17 Cells May Be Involved in the Pathogenesis of Autoimmune Damage in Hashimoto’s Thyroiditis. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072461
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072461