Interleukin-1 Family Cytokines in Liver Diseases
Joint Authors
Hayashi, Shuhei
Tsutsui, Hiroko
Cai, Xianbin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-15
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
The gene encoding IL-1 was sequenced more than 30 years ago, and many related cytokines, such as IL-18, IL-33, IL-36, IL-37, IL-38, IL-1 receptor antagonist (IL-1Ra), and IL-36Ra, have since been identified.
IL-1 is a potent proinflammatory cytokine and is involved in various inflammatory diseases.
Other IL-1 family ligands are critical for the development of diverse diseases, including inflammatory and allergic diseases.
Only IL-1Ra possesses the leader peptide required for secretion from cells, and many ligands require posttranslational processing for activation.
Some require inflammasome-mediated processing for activation and release, whereas others serve as alarmins and are released following cell membrane rupture, for example, by pyroptosis or necroptosis.
Thus, each ligand has the proper molecular process to exert its own biological functions.
In this review, we will give a brief introduction to the IL-1 family cytokines and discuss their pivotal roles in the development of various liver diseases in association with immune responses.
For example, an excess of IL-33 causes liver fibrosis in mice via activation and expansion of group 2 innate lymphoid cells to produce type 2 cytokines, resulting in cell conversion into pro-fibrotic M2 macrophages.
Finally, we will discuss the importance of IL-1 family cytokine-mediated molecular and cellular networks in the development of acute and chronic liver diseases.
American Psychological Association (APA)
Tsutsui, Hiroko& Cai, Xianbin& Hayashi, Shuhei. 2015. Interleukin-1 Family Cytokines in Liver Diseases. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1072471
Modern Language Association (MLA)
Tsutsui, Hiroko…[et al.]. Interleukin-1 Family Cytokines in Liver Diseases. Mediators of Inflammation No. 2015 (2015), pp.1-19.
https://search.emarefa.net/detail/BIM-1072471
American Medical Association (AMA)
Tsutsui, Hiroko& Cai, Xianbin& Hayashi, Shuhei. Interleukin-1 Family Cytokines in Liver Diseases. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1072471
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072471