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Th17 Cells in Type 1 Diabetes: Role in the Pathogenesis and Regulation by Gut Microbiome
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Type 1 diabetes (T1D) is an autoimmune disease which is characterized by progressive destruction of insulin producing pancreatic islet β cells.
The risk of developing T1D is determined by both genetic and environmental factors.
A growing body of evidence supports an important role of T helper type 17 (Th17) cells along with impaired T regulatory (Treg) cells in the development of T1D in animal models and humans.
Alteration of gut microbiota has been implicated to be responsible for the imbalance between Th17 and Treg cells.
However, there is controversy concerning a pathogenic versus protective role of Th17 cells in murine models of diabetes in the context of influence of gut microbiota.
In this review we will summarize current knowledge about Th17 cells and gut microbiota involved in T1D and propose Th17 targeted therapy in children with islet autoimmunity to prevent progression to overt diabetes.
American Psychological Association (APA)
Liu, Yu& Liu, Yu& Chu, Cong-Qiu. 2015. Th17 Cells in Type 1 Diabetes: Role in the Pathogenesis and Regulation by Gut Microbiome. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072477
Modern Language Association (MLA)
Liu, Yu…[et al.]. Th17 Cells in Type 1 Diabetes: Role in the Pathogenesis and Regulation by Gut Microbiome. Mediators of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1072477
American Medical Association (AMA)
Liu, Yu& Liu, Yu& Chu, Cong-Qiu. Th17 Cells in Type 1 Diabetes: Role in the Pathogenesis and Regulation by Gut Microbiome. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072477
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072477