The Role of Reactive Oxygen Species in Myelofibrosis and Related Neoplasms
Joint Authors
Hasselbalch, Hans Carl
Bjørn, Mads Emil
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Reactive oxygen species (ROS) have been implicated in a wide variety of disorders ranging between traumatic, infectious, inflammatory, and malignant diseases.
ROS are involved in inflammation-induced oxidative damage to cellular components including regulatory proteins and DNA.
Furthermore, ROS have a major role in carcinogenesis and disease progression in the myeloproliferative neoplasms (MPNs), where the malignant clone itself produces excess of ROS thereby creating a vicious self-perpetuating circle in which ROS activate proinflammatory pathways (NF-κB) which in turn create more ROS.
Targeting ROS may be a therapeutic option, which could possibly prevent genomic instability and ultimately myelofibrotic and leukemic transformation.
In regard to the potent efficacy of the ROS-scavenger N-acetyl-cysteine (NAC) in decreasing ROS levels, it is intriguing to consider if NAC treatment might benefit patients with MPN.
The encouraging results from studies in cystic fibrosis, systemic lupus erythematosus, and chronic obstructive pulmonary disease warrant such studies.
In addition, the antioxidative potential of the widely used agents, interferon-alpha2, statins, and JAK inhibitors, should be investigated as well.
A combinatorial approach using old agents with anticancer properties together with novel JAK1/2 inhibitors may open a new era for patients with MPNs, the outlook not only being “minimal residual disease” and potential cure but also a marked improvement in inflammation-mediated comorbidities.
American Psychological Association (APA)
Bjørn, Mads Emil& Hasselbalch, Hans Carl. 2015. The Role of Reactive Oxygen Species in Myelofibrosis and Related Neoplasms. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072486
Modern Language Association (MLA)
Bjørn, Mads Emil& Hasselbalch, Hans Carl. The Role of Reactive Oxygen Species in Myelofibrosis and Related Neoplasms. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072486
American Medical Association (AMA)
Bjørn, Mads Emil& Hasselbalch, Hans Carl. The Role of Reactive Oxygen Species in Myelofibrosis and Related Neoplasms. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072486
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072486