![](/images/graphics-bg.png)
Leukocytes: The Double-Edged Sword in Fibrosis
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Skin tissue scar formation and fibrosis are often characterized by the increased production and deposition of extracellular matrix components, accompanied by the accumulation of a vast number of myofibroblasts.
Scaring is strongly associated with inflammation and wound healing to regain tissue integrity in response to skin tissue injury.
However, increased and uncontrolled inflammation, repetitive injury, and individual predisposition might lead to fibrosis, a severe disorder resulting in the formation of dense and stiff tissue that loses the physical properties and physiological functions of normal tissue.
Fibrosis is an extremely complicated and multistage process in which bone marrow-derived leukocytes act as both pro- and antifibrotic agents, and therefore, few, if any, effective therapies are available for the most severe and lethal forms of fibrosis.
Herein, we discuss the current knowledge on the multidimensional impact of leukocytes on the induction of fibrosis, focusing on skin fibrosis.
American Psychological Association (APA)
Kryczka, Jakub& Boncela, Joanna. 2015. Leukocytes: The Double-Edged Sword in Fibrosis. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072487
Modern Language Association (MLA)
Kryczka, Jakub& Boncela, Joanna. Leukocytes: The Double-Edged Sword in Fibrosis. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072487
American Medical Association (AMA)
Kryczka, Jakub& Boncela, Joanna. Leukocytes: The Double-Edged Sword in Fibrosis. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072487
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072487