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Relation of Biomarkers of Inflammation and Oxidative Stress with Hypertension Occurrence in Lone Atrial Fibrillation
Joint Authors
Potpara, Tatjana
Polovina, Marija M.
Ostojic, Miodrag C.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We compared plasma levels of biomarkers of inflammation (CRP) and oxidation (oxLDL), determined at study inclusion in lone atrial fibrillation (LAF) patients (48.6±11.5 years; 74.0% men) and sinus rhythm controls (49.7±9.3 years; 72.7% men, P>0.05), and investigated the association of baseline CRP and oxLDL levels with the risk for vascular disease (VD) development (hypertension, cerebrovascular disease, coronary/peripheral artery disease, and pulmonary embolism) during prospective follow-up.
Baseline CRP (1.2 [0.7–1.9] mg/L versus 1.1 [0.7–1.6] mg/L) and oxLDL levels (66.3±21.2 U/L versus 57.1±14.6 U/L) were higher in LAF patients (both P<0.05).
Following a median of 36 months, incident VD occurred in 14 (28.0%) LAF patients, all of whom developed arterial hypertension, and in 5 (11.4%) controls (hypertension, n=4; coronary artery disease, n=1), P<0.05.
LAF patients developed VD more frequently and at a younger age.
Both CRP (HR, 2.54; 95% CI, 1.26–5.12; P=0.009) and oxLDL (HR, 2.24; 95% CI, 1.14–4.40; P=0.019) were multivariate predictors of incident hypertension in LAF patients, but not in the controls.
Further research should clarify clinical relevance of investigated biomarkers for risk stratification and treatment of LAF patients.
American Psychological Association (APA)
Polovina, Marija M.& Ostojic, Miodrag C.& Potpara, Tatjana. 2015. Relation of Biomarkers of Inflammation and Oxidative Stress with Hypertension Occurrence in Lone Atrial Fibrillation. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072488
Modern Language Association (MLA)
Polovina, Marija M.…[et al.]. Relation of Biomarkers of Inflammation and Oxidative Stress with Hypertension Occurrence in Lone Atrial Fibrillation. Mediators of Inflammation No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1072488
American Medical Association (AMA)
Polovina, Marija M.& Ostojic, Miodrag C.& Potpara, Tatjana. Relation of Biomarkers of Inflammation and Oxidative Stress with Hypertension Occurrence in Lone Atrial Fibrillation. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072488
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072488