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Tissue Transglutaminase-Regulated Transformed Growth Factor-β1 in the Parasite Links Schistosoma japonicum Infection with Liver Fibrosis
Joint Authors
Tang, Juanjuan
Ji, Xiaofang
Zhu, Xunmin
Li, Yinyan
Yan, Suikai
Li, Zi
Zhao, Jingjing
Gao, Zhiyan
Li, Xiaomin
Su, Fang
Fung, Ming Chui
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Transforming growth factor (TGF-β1) is among the strongest factors of liver fibrogenesis, but its association with Schistosoma-caused liver fibrosis is controversial.
Tissue transglutaminase (tTG) is the principal enzyme controlling TGF-β1 maturation and contributes to Sj-infected liver fibrosis.
Here we aim to explore the consistency between tTG and TGF-β1 and TGF-β1 source and its correlation with liver fibrosis after Sj-infection.
TGF-β1 was upregulated at weeks 6 and 8 upon liver fibrosis induction.
During tTG inhibition, TGF-β1 level decreased in sera and liver of infected mice.
TGF-β1 showed positive staining in liver containing Sj adult worms and eggs.
TGF-β1 was also detected in Sj adult worm sections, soluble egg antigen and Sj adult worm antigen, and adult worms’ culture medium.
The TGF-β1 mature peptide cDNA sequence and its extended sequence were amplified through RT-PCR and RACE-PCR using adult worms as template, and sequence is analyzed and loaded to NCBI GenBank (number GQ338152.1).
TGF-β1 transcript in Sj eggs was higher than in adult worms.
In Sj-infected liver, transcriptional level of TGF-β1 from Sj, but not mouse liver, correlated with liver fibrosis extent.
This study provides evidence that tTG regulates TGF-β1 and illustrates the importance of targeting tTG in treating Sj infection-induced fibrosis.
American Psychological Association (APA)
Tang, Juanjuan& Zhu, Xunmin& Zhao, Jingjing& Fung, Ming Chui& Li, Yinyan& Gao, Zhiyan…[et al.]. 2015. Tissue Transglutaminase-Regulated Transformed Growth Factor-β1 in the Parasite Links Schistosoma japonicum Infection with Liver Fibrosis. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072498
Modern Language Association (MLA)
Tang, Juanjuan…[et al.]. Tissue Transglutaminase-Regulated Transformed Growth Factor-β1 in the Parasite Links Schistosoma japonicum Infection with Liver Fibrosis. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072498
American Medical Association (AMA)
Tang, Juanjuan& Zhu, Xunmin& Zhao, Jingjing& Fung, Ming Chui& Li, Yinyan& Gao, Zhiyan…[et al.]. Tissue Transglutaminase-Regulated Transformed Growth Factor-β1 in the Parasite Links Schistosoma japonicum Infection with Liver Fibrosis. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072498
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072498