Hydrogen-Rich Saline Attenuates Acute Renal Injury in Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting ROS and NF-κB Pathway
Joint Authors
Wenhong, Deng
Weixing, Wang
Chen, Chen
Shi, Qiao
Liao, Kang-Shu
Zhao, Kai-Liang
Zuo, Teng
Yu, Jia
Guo, Wen-Yi
He, Xiao-Bo
Abliz, Ablikim
Wang, Peng
Zhao, Liang
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-23
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Hydrogen (H2), a new antioxidant, was reported to reduce •OH and ONOO− selectively and inhibit certain proinflammatory mediators to product, without disturbing metabolic redox reactions or ROS involved in cell signaling.
We herein aim to explore its protective effects on acute renal injury in sodium taurocholate-induced acute pancreatitis and its possible mechanisms.
Rats were injected with hydrogen-rich saline (HRS group) or normal saline (SO and SAP group) through tail intravenously (6 mL/kg) and compensated subcutaneously (20 mL/kg) after successful modeling.
Results showed that hydrogen-rich saline attenuated the following: (1) serum Cr and BUN, (2) pancreatic and renal pathological injuries, (3) renal MDA, (4) renal MPO, (5) serum IL-1β, IL-6, and renal TNF- α, HMGB1, and (6) tyrosine nitration, IκB degradation, and NF-κB activation in renal tissues.
In addition, it increased the level of IL-10 and SOD activity in renal tissues.
These results proved that hydrogen-rich saline attenuates acute renal injury in sodium taurocholate-induced acute pancreatitis, presumably because of its detoxification activity against excessive ROS, and inhibits the activation of NF-κB by affecting IκB nitration and degradation.
Our findings highlight the potential value of hydrogen-rich saline as a new therapeutic method on acute renal injury in severe acute pancreatitis clinically.
American Psychological Association (APA)
Shi, Qiao& Liao, Kang-Shu& Zhao, Kai-Liang& Weixing, Wang& Zuo, Teng& Wenhong, Deng…[et al.]. 2015. Hydrogen-Rich Saline Attenuates Acute Renal Injury in Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting ROS and NF-κB Pathway. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072510
Modern Language Association (MLA)
Shi, Qiao…[et al.]. Hydrogen-Rich Saline Attenuates Acute Renal Injury in Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting ROS and NF-κB Pathway. Mediators of Inflammation No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1072510
American Medical Association (AMA)
Shi, Qiao& Liao, Kang-Shu& Zhao, Kai-Liang& Weixing, Wang& Zuo, Teng& Wenhong, Deng…[et al.]. Hydrogen-Rich Saline Attenuates Acute Renal Injury in Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting ROS and NF-κB Pathway. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072510
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072510