EPSTI1 Is Involved in IL-28A-Mediated Inhibition of HCV Infection
Joint Authors
Meng, Xianghe
Yang, Darong
Yu, Rong
Zhu, Haizhen
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
It has been reported that IFN-λs inhibit HCV replication in vitro.
But the mechanisms of how IL-28A conducts antiviral activity and the functions of IL-28A-induced ISGs (IFN-stimulated genes) are not fully understood.
In this study, we found that IL-28A has the antiviral effect on HCV life cycle including viral replication, assembly, and release.
IL-28A and IFN-α synergistically inhibit virus replication.
EPSTI1 (epithelial-stromal interaction 1), one of IL-28A-induced ISGs, plays a vital role in IL-28A-mediated antiviral activity.
Furthermore, forced expression of EPSTI1 effectively inhibits HCV replication in the absence of interferon treatment, and knockdown of EPSTI1 contributes to viral enhancement.
EPSTI1 can activate PKR promoter and induce several PKR-dependent genes, including IFN-β, IFIT1, OAS1, and RNase L, which is responsible for EPSTI1-mediated antiviral activity.
American Psychological Association (APA)
Meng, Xianghe& Yang, Darong& Yu, Rong& Zhu, Haizhen. 2015. EPSTI1 Is Involved in IL-28A-Mediated Inhibition of HCV Infection. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072527
Modern Language Association (MLA)
Meng, Xianghe…[et al.]. EPSTI1 Is Involved in IL-28A-Mediated Inhibition of HCV Infection. Mediators of Inflammation No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1072527
American Medical Association (AMA)
Meng, Xianghe& Yang, Darong& Yu, Rong& Zhu, Haizhen. EPSTI1 Is Involved in IL-28A-Mediated Inhibition of HCV Infection. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072527
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072527