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Relationship between Prolactin Plasma Levels and White Matter Volume in Women with Multiple Sclerosis
Joint Authors
De Giglio, L.
Marinelli, F.
Contessa, G. M.
Gurreri, F.
Piattella, M. C.
De Angelis, F.
Barletta, V. T.
Tomassini, V.
Pozzilli, Carlo
Prosperini, Luca
Pantano, Patrizia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
The role of prolactin (PRL) on tissue injury and repair mechanisms in multiplesclerosis (MS) remains unclear.
The aim of this work was to investigate the relationship between PRL plasma levels and brain damage as measured by magnetic resonance imaging (MRI).
Methods.
We employed a chemiluminescence immunoassay for measuring plasma levels of PRL.
We used a 1.5 T scanner to acquire images and Jim 4.0 and SIENAX software to analyse them.
Results.
We included 106 women with relapsing remitting (RR) MS and stable disease in the lasttwo months.
There was no difference in PRL plasma levels between patients with and without gadolinium enhancement on MRI.
PRL plasma levels correlated with white matter volume (WMV) (rho = 0.284, p=0.014) but not with grey matter volume (GMV).
Moreover, PRL levels predicted changes in WMV (Beta: 984, p=0.034).
Conclusions.
Our data of a positive association between PRL serum levels and WMV support the role of PRL in promoting myelin repair as documented in animal models of demyelination.
The lack of an increase of PRL in the presence of gadolinium enhancement, contrasts with the view considering this hormone as an immune-stimulating and detrimental factor in the inflammatory process associated with MS.
American Psychological Association (APA)
De Giglio, L.& Marinelli, F.& Prosperini, Luca& Contessa, G. M.& Gurreri, F.& Piattella, M. C.…[et al.]. 2015. Relationship between Prolactin Plasma Levels and White Matter Volume in Women with Multiple Sclerosis. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1072534
Modern Language Association (MLA)
De Giglio, L.…[et al.]. Relationship between Prolactin Plasma Levels and White Matter Volume in Women with Multiple Sclerosis. Mediators of Inflammation No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1072534
American Medical Association (AMA)
De Giglio, L.& Marinelli, F.& Prosperini, Luca& Contessa, G. M.& Gurreri, F.& Piattella, M. C.…[et al.]. Relationship between Prolactin Plasma Levels and White Matter Volume in Women with Multiple Sclerosis. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1072534
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072534