Progranulin Is Associated with Disease Activity in Patients with Rheumatoid Arthritis
Joint Authors
Andrés Cerezo, Lucie
Kuklová, Markéta
Hulejová, Hana
Vernerová, Zdeňka
Kaspříková, Nikola
Veigl, David
Pavelka, Karel
Vencovský, Jiří
Šenolt, Ladislav
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
Progranulin (PGRN) is implicated in the pathogenesis of rheumatoid arthritis (RA).
The aim of this study was to assess the relationship between PGRN and disease activity in RA.
Methods.
PGRN levels were evaluated in patients with RA (n=47) and OA (n=42) and healthy controls (n=41).
Immunohistochemical analysis of PGRN in synovial tissues was performed.
The association between PGRN and C-reactive protein (CRP), disease activity score (DAS28-CRP), and health assessment questionnaire (HAQ) was studied.
Results.
Circulating PGRN was elevated in patients with RA and OA compared to healthy controls (227.1±100.2 and 221.5±102.5 versus 128.1±34.7 ng/mL; P<0.001).
Synovial fluid levels of PGRN were higher in patients with RA compared to OA (384.5±275.3 versus 241.4±165.2 ng/mL; P=0.002).
PGRN expression was significantly upregulated in the synovial tissue of RA patients particularly in the inflammatory infiltrates.
Serum PGRN levels correlated with DAS28 (r=0.327, P=0.049) and HAQ score (r=0.323, P=0.032), while synovial fluid PGRN correlated only with HAQ (r=0.310, P=0.043) in patients with RA.
PGRN levels were not associated with CRP or autoantibodies.
Conclusions.
This study demonstrates increased PGRN expression at local sites of inflammation and association between PGRN levels, disease activity, and functional impairment in patients with RA.
American Psychological Association (APA)
Andrés Cerezo, Lucie& Kuklová, Markéta& Hulejová, Hana& Vernerová, Zdeňka& Kaspříková, Nikola& Veigl, David…[et al.]. 2015. Progranulin Is Associated with Disease Activity in Patients with Rheumatoid Arthritis. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1072537
Modern Language Association (MLA)
Andrés Cerezo, Lucie…[et al.]. Progranulin Is Associated with Disease Activity in Patients with Rheumatoid Arthritis. Mediators of Inflammation No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1072537
American Medical Association (AMA)
Andrés Cerezo, Lucie& Kuklová, Markéta& Hulejová, Hana& Vernerová, Zdeňka& Kaspříková, Nikola& Veigl, David…[et al.]. Progranulin Is Associated with Disease Activity in Patients with Rheumatoid Arthritis. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1072537
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072537