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Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications
Joint Authors
Bartoloni, Elena
Gerli, Roberto
Manetti, Mirko
Ibba-Manneschi, Lidia
Valentini, Valentina
Terenzi, Riccardo
Caterbi, Sara
Alunno, Alessia
Bistoni, Onelia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In recent years several studies investigated the role of T lymphocyte subpopulations in the pathogenesis of rheumatoid arthritis (RA).
Pathogenic Th17 cells mediate pannus growth, osteoclastogenesis, and synovial neoangiogenesis; hence they are key players in the development of the disease.
On the other hand, regulatory T (Treg) cells are a T cell subset whose peculiar function is to suppress autoreactive lymphocytes.
The imbalance between Th17 and Treg cells has been identified as a crucial event in the pathogenesis of RA.
In addition, the effects of currently employed RA therapeutic strategies on these lymphocyte subpopulations have been extensively investigated.
This review article aims to discuss current knowledge on Treg and Th17 cells in RA and possible implications of their therapeutic targeting in this disorder.
American Psychological Association (APA)
Alunno, Alessia& Manetti, Mirko& Caterbi, Sara& Ibba-Manneschi, Lidia& Bistoni, Onelia& Bartoloni, Elena…[et al.]. 2015. Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072540
Modern Language Association (MLA)
Alunno, Alessia…[et al.]. Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications. Mediators of Inflammation No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1072540
American Medical Association (AMA)
Alunno, Alessia& Manetti, Mirko& Caterbi, Sara& Ibba-Manneschi, Lidia& Bistoni, Onelia& Bartoloni, Elena…[et al.]. Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072540