Genetic and Environmental Influences on Retinopathy of Prematurity
Joint Authors
Ortega Molina, José María
Solans Pérez de Larraya, Ana
Anaya-Alaminos, R.
Uberos-Fernández, J.
Chaves-Samaniego, M. J.
Salgado-Miranda, A.
Piñar-Molina, R.
Jerez-Calero, A.
García-Serrano, J. L.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
The goals were to isolate and study the genetic susceptibility to retinopathy of prematurity (ROP), as well as the gene-environment interaction established in this disease.
Methods.
A retrospective study (2000–2014) was performed about the heritability of retinopathy of prematurity in 257 infants who were born at a gestational age of ≤32 weeks.
The ROP was studied and treated by a single pediatric ophthalmologist.
A binary logistic regression analysis was completed between the presence or absence of ROP and the predictor variables.
Results.
Data obtained from 38 monozygotic twins, 66 dizygotic twins, and 153 of simple birth were analyzed.
The clinical features of the cohorts of monozygotic and dizygotic twins were not significantly different.
Genetic factors represented 72.8% of the variability in the stage of ROP, environmental factors 23.08%, and random factors 4.12%.
The environmental variables representing the highest risk of ROP were the number of days of tracheal intubation (p < 0.001), postnatal weight gain (p = 0.001), and development of sepsis (p = 0.0014).
Conclusion.
The heritability of ROP was found to be 0.73.
The environmental factors regulate and modify the expression of the genetic code.
American Psychological Association (APA)
Ortega Molina, José María& Anaya-Alaminos, R.& Uberos-Fernández, J.& Solans Pérez de Larraya, Ana& Chaves-Samaniego, M. J.& Salgado-Miranda, A.…[et al.]. 2015. Genetic and Environmental Influences on Retinopathy of Prematurity. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072546
Modern Language Association (MLA)
Ortega Molina, José María…[et al.]. Genetic and Environmental Influences on Retinopathy of Prematurity. Mediators of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1072546
American Medical Association (AMA)
Ortega Molina, José María& Anaya-Alaminos, R.& Uberos-Fernández, J.& Solans Pérez de Larraya, Ana& Chaves-Samaniego, M. J.& Salgado-Miranda, A.…[et al.]. Genetic and Environmental Influences on Retinopathy of Prematurity. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072546
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072546