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Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family
Joint Authors
Sziksz, Erna
Pap, Domonkos
Lippai, Rita
Béres, Nóra Judit
Fekete, Andrea
Szabó, Attila J.
Vannay, Ádám
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-24
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Importance of chronic fibroproliferative diseases (FDs) including pulmonary fibrosis, chronic kidney diseases, inflammatory bowel disease, and cardiovascular or liver fibrosis is rapidly increasing and they have become a major public health problem.
According to some estimates about 45% of all deaths are attributed to FDs in the developed world.
Independently of their etiology the common hallmark of FDs is chronic inflammation.
Infiltrating immune cells, endothelial, epithelial, and other resident cells of the injured organ release an orchestra of inflammatory mediators, which stimulate the proliferation and excessive extracellular matrix (ECM) production of myofibroblasts, the effector cells of organ fibrosis.
Abnormal amount of ECM disturbs the original organ architecture leading to the decline of function.
Although our knowledge is rapidly expanding, we still have neither a diagnostic tool to detect nor a drug to specifically target fibrosis.
Therefore, there is an urgent need for the more comprehensive understanding of the pathomechanism of fibrosis and development of novel diagnostic and therapeutic strategies.
In the present review we provide an overview of the common key mediators of organ fibrosis highlighting the role of interleukin-10 (IL-10) cytokine family members (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26), which recently came into focus as tissue remodeling-related inflammatory cytokines.
American Psychological Association (APA)
Sziksz, Erna& Pap, Domonkos& Lippai, Rita& Béres, Nóra Judit& Fekete, Andrea& Szabó, Attila J.…[et al.]. 2015. Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1072548
Modern Language Association (MLA)
Sziksz, Erna…[et al.]. Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family. Mediators of Inflammation No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1072548
American Medical Association (AMA)
Sziksz, Erna& Pap, Domonkos& Lippai, Rita& Béres, Nóra Judit& Fekete, Andrea& Szabó, Attila J.…[et al.]. Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1072548
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072548