Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia
Joint Authors
Molfino, Alessio
Gioia, Gianfranco
Fanelli, Filippo Rossi
Laviano, Alessandro
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Inflammation characterizes the course of acute and chronic diseases and is largely responsible for the metabolic and behavioral changes occurring during the clinical journey of patients.
Robust data indicate that, during cancer, functional modifications within brain areas regulating energy homeostasis contribute to the onset of anorexia, reduced food intake, and increased catabolism of muscle mass and adipose tissue.
In particular, functional changes are associated with increased hypothalamic concentration of proinflammatory cytokines, which suggests that neuroinflammation may represent the adaptive response of the brain to peripheral challenges, including tumor growth.
Within this conceptual framework, the vagus nerve appears to be involved in conveying alert signals to the hypothalamus, whereas hypothalamic serotonin appears to contribute to triggering catabolic signals.
American Psychological Association (APA)
Molfino, Alessio& Gioia, Gianfranco& Fanelli, Filippo Rossi& Laviano, Alessandro. 2015. Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072580
Modern Language Association (MLA)
Molfino, Alessio…[et al.]. Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia. Mediators of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1072580
American Medical Association (AMA)
Molfino, Alessio& Gioia, Gianfranco& Fanelli, Filippo Rossi& Laviano, Alessandro. Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072580
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072580