Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats
Joint Authors
Alıcı, Suleyman
Alici, Ozlem
Kavakli, Havva Sahin
Koca, Cemile
Altintas, Neriman Defne
Aydin, Murat
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background and Aim.
The aim of this study was to determine the actions of caffeic acid phenethyl ester (CAPE) on the changes of endothelin-1 (ET-1) level, tumor necrosis factor- (TNF-) alpha, and oxidative stress parameters such as superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in experimental sepsis model in rats.
Materials and Methods.
Twenty-four rats were randomly divided into three experimental groups: sham (group 1), sepsis (group 2), and sepsis + CAPE (group 3), n = 8 each.
CAPE was administered (10 µmol/kg) intraperitoneally to group 3 before sepsis induction.
Serum ET-1, serum TNF-alpha, tissue SOD activity, and tissue MDA levels were measured in all groups.
Results.
Pretreatment with CAPE decreased ET-1, TNF-alpha, and MDA levels in sepsis induced rats.
Additionally SOD activities were higher in rats pretreated with CAPE after sepsis induction.
Conclusion.
Our results demonstrate that CAPE may have a beneficial effect on ET and TNF-alpha levels and oxidative stress parameters induced by sepsis in experimental rat models.
Therefore treatment with CAPE can be used to avoid devastating effects of sepsis.
American Psychological Association (APA)
Alici, Ozlem& Kavakli, Havva Sahin& Koca, Cemile& Altintas, Neriman Defne& Aydin, Murat& Alıcı, Suleyman. 2015. Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1072588
Modern Language Association (MLA)
Alici, Ozlem…[et al.]. Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats. Mediators of Inflammation No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1072588
American Medical Association (AMA)
Alici, Ozlem& Kavakli, Havva Sahin& Koca, Cemile& Altintas, Neriman Defne& Aydin, Murat& Alıcı, Suleyman. Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1072588
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072588