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Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms
Author
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The alternatively activated or M2 macrophages are immune cells with high phenotypic heterogeneity and are governing functions at the interface of immunity, tissue homeostasis, metabolism, and endocrine signaling.
Today the M2 macrophages are identified based on the expression pattern of a set of M2 markers.
These markers are transmembrane glycoproteins, scavenger receptors, enzymes, growth factors, hormones, cytokines, and cytokine receptors with diverse and often yet unexplored functions.
This review discusses whether these M2 markers can be reliably used to identify M2 macrophages and define their functional subdivisions.
Also, it provides an update on the novel signals of the tissue environment and the neuroendocrine system which shape the M2 activation.
The possible evolutionary roots of the M2 macrophage functions are also discussed.
American Psychological Association (APA)
Rőszer, Tamás. 2015. Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1072590
Modern Language Association (MLA)
Rőszer, Tamás. Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms. Mediators of Inflammation No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1072590
American Medical Association (AMA)
Rőszer, Tamás. Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1072590
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072590