Modulatory Effects of Astragalus Polysaccharides on T-Cell Polarization in Mice with Polymicrobial Sepsis
Joint Authors
Hou, Yu-Chen
Wu, Jin-Ming
Lin, Ming-Tsan
Wang, Ming-Yang
Wu, Ming-Hsun
Chen, Kuen-Yuan
Yeh, Sung-Ling
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
This study evaluated the impact of different doses of Astragalus polysaccharides (APS) on the functional status and phenotype of T cells during polymicrobial sepsis.
Methods.
On day 1 after cecal ligation and puncture, mice were treated with either saline, 100 (A100), 200 (A200), or 400 mg APS/kg body weight (BW) (A400) by an intraperitoneal injection daily for 4 days.
All mice were sacrificed 5 days after the operation.
Results.
APS treatment reversed the sepsis-induced decrement in the T helper (Th) cell population, and the percentage of activated Th cells also increased in the spleen and Peyer’s patches.
APS administration downregulated the percentages of circulating Th2 cells and regulatory T cells (Treg), and the percentage of Th17 cells in blood was upregulated in the A400 group.
Weight loss and kidney injury were attenuated in the A100 and A200 groups but not in the A400 group at the end of the study.
Conclusions.
Treatments with 100 and 200 mg APS/kg BW reduced Treg populations and elicited a more-balanced Th1/Th2 response that consequently attenuated immunosuppression in polymicrobial sepsis.
High-dose APS administration led to excessive responses of Th17 cells which may have adverse effects in sepsis-induced organ injury.
American Psychological Association (APA)
Hou, Yu-Chen& Wu, Jin-Ming& Wang, Ming-Yang& Wu, Ming-Hsun& Chen, Kuen-Yuan& Yeh, Sung-Ling…[et al.]. 2015. Modulatory Effects of Astragalus Polysaccharides on T-Cell Polarization in Mice with Polymicrobial Sepsis. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072598
Modern Language Association (MLA)
Hou, Yu-Chen…[et al.]. Modulatory Effects of Astragalus Polysaccharides on T-Cell Polarization in Mice with Polymicrobial Sepsis. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072598
American Medical Association (AMA)
Hou, Yu-Chen& Wu, Jin-Ming& Wang, Ming-Yang& Wu, Ming-Hsun& Chen, Kuen-Yuan& Yeh, Sung-Ling…[et al.]. Modulatory Effects of Astragalus Polysaccharides on T-Cell Polarization in Mice with Polymicrobial Sepsis. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072598
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072598