Natural Products: Insights into Leishmaniasis Inflammatory Response
Joint Authors
Mazotto, Ana Maria
Rodrigues, Igor A.
Cardoso, Verônica
Alves, Renan L.
Amaral, Ana Claudia F.
Pinheiro, Anderson S.
Vermelho, Alane Beatriz
Silva, Jefferson Rocha de A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Leishmaniasis is a vector-borne disease that affects several populations worldwide, against which there are no vaccines available and the chemotherapy is highly toxic.
Depending on the species causing the infection, the disease is characterized by commitment of tissues, including the skin, mucous membranes, and internal organs.
Despite the relevance of host inflammatory mediators on parasite burden control, Leishmania and host immune cells interaction may generate an exacerbated proinflammatory response that plays an important role in the development of leishmaniasis clinical manifestations.
Plant-derived natural products have been recognized as bioactive agents with several properties, including anti-protozoal and anti-inflammatory activities.
The present review focuses on the antileishmanial activity of plant-derived natural products that are able to modulate the inflammatory response in vitro and in vivo.
The capability of crude extracts and some isolated substances in promoting an anti-inflammatory response during Leishmania infection may be used as part of an effective strategy to fight the disease.
American Psychological Association (APA)
Rodrigues, Igor A.& Mazotto, Ana Maria& Cardoso, Verônica& Alves, Renan L.& Amaral, Ana Claudia F.& Silva, Jefferson Rocha de A.…[et al.]. 2015. Natural Products: Insights into Leishmaniasis Inflammatory Response. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072601
Modern Language Association (MLA)
Rodrigues, Igor A.…[et al.]. Natural Products: Insights into Leishmaniasis Inflammatory Response. Mediators of Inflammation No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1072601
American Medical Association (AMA)
Rodrigues, Igor A.& Mazotto, Ana Maria& Cardoso, Verônica& Alves, Renan L.& Amaral, Ana Claudia F.& Silva, Jefferson Rocha de A.…[et al.]. Natural Products: Insights into Leishmaniasis Inflammatory Response. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072601
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072601