The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme with a crucial role in the maintenance of genomic stability.
In addition to the role of PARP-1 in DNA repair, multiple studies have also demonstrated its involvement in several inflammatory diseases, such as septic shock, asthma, atherosclerosis, and stroke, as well as in cancer.
In these diseases, the pharmacological inhibition of PARP-1 has shown a beneficial effect, suggesting that PARP-1 regulates their inflammatory processes.
In recent years, we have studied the role of PARP-1 in rheumatoid arthritis, as have other researchers, and the results have shown that PARP-1 has an important function in the development of this disease.
This review summarizes current knowledge on the effects of PARP-1 in rheumatoid arthritis.
American Psychological Association (APA)
García, Samuel& Conde, Carmen. 2015. The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072602
Modern Language Association (MLA)
García, Samuel& Conde, Carmen. The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis. Mediators of Inflammation No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1072602
American Medical Association (AMA)
García, Samuel& Conde, Carmen. The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072602
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072602
