Atorvastatin Improves Inflammatory Response in Atherosclerosis by Upregulating the Expression of GARP
Joint Authors
Meng, Kai
Yu, Kunwu
Wu, Bangwei
Zhao, Xiaoqi
Liu, Yuzhou
Zhong, Yucheng
Liu, Bo
Shi, Huairui
Zhu, Ruirui
Zhang, Wei
Zeng, Qiu-tang
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Regulatory T cells play an important role in the progression of atherosclerosis.
GARP is a newly biological membrane molecule existed on activated Tregs, which is related to the release of TGF-β.
The antiatherosclerosis effects of statins partly depend on their multiple immune modulatory potencies.
In this paper, we present that atorvastatin could upregulate the expression of GARP and TGF-β in CD4+ T cells and increase the numbers of CD4+LAP+ and CD4+Foxp3+ regulatory T cells in ApoE−/− mice.
Also, we indicate that atorvastatin promotes the aggregation of GARP+ and Foxp3+ cells and secretory of the TGF-β1 in atherosclerotic plaques.
Furthermore, we prove that atorvastatin could delay the procession of atherosclerosis and improve the stability of atherosclerotic plaques.
Interestingly, we report that inhibition of GARP distinctly inhibits the anti-inflammatory effects of atorvastatin.
We conclude that atorvastatin improves the inflammatory response in atherosclerosis partly by upregulating the expression of GARP on regulatory T cells.
American Psychological Association (APA)
Zhao, Xiaoqi& Liu, Yuzhou& Zhong, Yucheng& Liu, Bo& Yu, Kunwu& Shi, Huairui…[et al.]. 2015. Atorvastatin Improves Inflammatory Response in Atherosclerosis by Upregulating the Expression of GARP. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072604
Modern Language Association (MLA)
Zhao, Xiaoqi…[et al.]. Atorvastatin Improves Inflammatory Response in Atherosclerosis by Upregulating the Expression of GARP. Mediators of Inflammation No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1072604
American Medical Association (AMA)
Zhao, Xiaoqi& Liu, Yuzhou& Zhong, Yucheng& Liu, Bo& Yu, Kunwu& Shi, Huairui…[et al.]. Atorvastatin Improves Inflammatory Response in Atherosclerosis by Upregulating the Expression of GARP. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072604
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072604