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Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease
Joint Authors
Caram, L. M. O.
Amaral, R. A. F.
Ferrari, R.
Tanni, S. E.
Correa, C. R.
Paiva, S. A. R.
Godoy, I.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Vitamin A is essential for the preservation and integrity of the lung epithelium and exerts anti-inflammatory effects.
Objective.
Evaluating vitamin A in the serum and sputum and testing its correlation with inflammatory markers in individuals with or without COPD.
Methods.
We evaluated dietary intake, serum and sputum vitamin A, tumor necrosis factor alpha, interleukin- (IL-) 6, IL-8, and C-reactive protein in 50 COPD patients (age = 64.0 ± 8.8 y; FEV1 (forced expiratory volume in the first second) (%) = 49.8 ± 16.8) and 50 controls (age = 48.5 ± 7.4 y; FEV1 (%) = 110.0 ± 15.7).
Results.
COPD exhibited lower serum vitamin A (1.8 (1.2–2.1) versus 2.1 (1.8–2.4) μmol/L, P<0.001) and lower vitamin A intake (636.9 (339.6–1349.6) versus 918.0 (592.1–1654.6) RAE, P=0.05) when compared with controls.
Sputum concentration of vitamin A was not different between groups.
Sputum vitamin A and neutrophils were negatively correlated (R2=-0.26; P=0.03).
Smoking (0.197, P=0.042) exhibited positive association with serum vitamin A.
COPD was associated with lower serum concentrations of vitamin A without relationship with the systemic inflammation.
Conclusions.
Serum concentration of vitamin A is negatively associated with the presence of COPD and positively associated with smoking status.
Sputum retinol is quantifiable and is negatively influenced by neutrophils.
Although COPD patients exhibited increased inflammation it was not associated with serum retinol.
American Psychological Association (APA)
Caram, L. M. O.& Amaral, R. A. F.& Ferrari, R.& Tanni, S. E.& Correa, C. R.& Paiva, S. A. R.…[et al.]. 2015. Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1072618
Modern Language Association (MLA)
Caram, L. M. O.…[et al.]. Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease. Mediators of Inflammation No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1072618
American Medical Association (AMA)
Caram, L. M. O.& Amaral, R. A. F.& Ferrari, R.& Tanni, S. E.& Correa, C. R.& Paiva, S. A. R.…[et al.]. Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1072618
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072618