Cytokine Regulation of Microenvironmental Cells in Myeloproliferative Neoplasms
Joint Authors
Hoermann, Gregor
Greiner, Georg
Valent, Peter
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-12
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The term myeloproliferative neoplasms (MPN) refers to a heterogeneous group of diseases including not only polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), but also chronic myeloid leukemia (CML), and systemic mastocytosis (SM).
Despite the clinical and biological differences between these diseases, common pathophysiological mechanisms have been identified in MPN.
First, aberrant tyrosine kinase signaling due to somatic mutations in certain driver genes is common to these MPN.
Second, alterations of the bone marrow microenvironment are found in all MPN types and have been implicated in the pathogenesis of the diseases.
Finally, elevated levels of proinflammatory and microenvironment-regulating cytokines are commonly found in all MPN-variants.
In this paper, we review the effects of MPN-related oncogenes on cytokine expression and release and describe common as well as distinct pathogenetic mechanisms underlying microenvironmental changes in various MPN.
Furthermore, targeting of the microenvironment in MPN is discussed.
Such novel therapies may enhance the efficacy and may overcome resistance to established tyrosine kinase inhibitor treatment in these patients.
Nevertheless, additional basic studies on the complex interplay of neoplastic and stromal cells are required in order to optimize targeting strategies and to translate these concepts into clinical application.
American Psychological Association (APA)
Hoermann, Gregor& Greiner, Georg& Valent, Peter. 2015. Cytokine Regulation of Microenvironmental Cells in Myeloproliferative Neoplasms. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1072620
Modern Language Association (MLA)
Hoermann, Gregor…[et al.]. Cytokine Regulation of Microenvironmental Cells in Myeloproliferative Neoplasms. Mediators of Inflammation No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1072620
American Medical Association (AMA)
Hoermann, Gregor& Greiner, Georg& Valent, Peter. Cytokine Regulation of Microenvironmental Cells in Myeloproliferative Neoplasms. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1072620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072620