IL-33 Aggravates DSS-Induced Acute Colitis in Mouse Colon Lamina Propria by Enhancing Th2 Cell Responses
Joint Authors
Zhang, Xiaoqing
Zhu, Junfeng
Yang, Fangli
Sang, Lixuan
Zhai, Jingbo
Yue, Dan
Li, Shengjun
Li, Yan
Lu, Changlong
Sun, Xun
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Interleukin- (IL-) 33, a member of the IL-1 cytokine family, is an important modulator of the immune system associated with several immune-mediated diseases.
IL-33 was expressed in high level on epithelial cells of intestinal tract.
It suggested that IL-33 plays a potential role in inflammatory bowel diseases (IBD).
We investigated the role of interleukin- (IL-) 33 in dextran sulphate sodium- (DSS-) induced acute colitis in mice using recombinant mouse IL-33 protein (rIL-33).
We found that DSS-induced acute colitis was aggravated by rIL-33 treatment.
rIL-33-treated DSS mice showed markedly reduced levels of interferon- (IFN-)γ and IL-17A in their colon lamina propria lymphocytes (LPL), but the levels of Th2 cytokines, such as IL-5 and IL-13, in these cells were significantly increased, compared to DSS mice treated with PBS.
Our results suggested that IL-33 stimulated CD4+T cells and caused the cell to adopt a Th2-type response but at the same time suppressed Th17 and Th1 cell responses.
Therefore, IL-33 may be involved in pathogenesis of DSS-induced acute colitis by promoting Th2 cell response in intestinal mucosa of mice.
Modulation of IL-33/ST2 signaling by monoclonal antibody (mAb) could be a novel biological therapy in DSS-induced acute colitis.
American Psychological Association (APA)
Zhu, Junfeng& Yang, Fangli& Sang, Lixuan& Zhai, Jingbo& Zhang, Xiaoqing& Yue, Dan…[et al.]. 2015. IL-33 Aggravates DSS-Induced Acute Colitis in Mouse Colon Lamina Propria by Enhancing Th2 Cell Responses. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072634
Modern Language Association (MLA)
Zhu, Junfeng…[et al.]. IL-33 Aggravates DSS-Induced Acute Colitis in Mouse Colon Lamina Propria by Enhancing Th2 Cell Responses. Mediators of Inflammation No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1072634
American Medical Association (AMA)
Zhu, Junfeng& Yang, Fangli& Sang, Lixuan& Zhai, Jingbo& Zhang, Xiaoqing& Yue, Dan…[et al.]. IL-33 Aggravates DSS-Induced Acute Colitis in Mouse Colon Lamina Propria by Enhancing Th2 Cell Responses. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072634
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072634