Increased Th17Treg Ratio in Poststroke Fatigue
Joint Authors
Liu, Xinjing
Kenkare, Komal
Li, Shanshan
Desai, Varsha
Wong, John
Luo, Xun
Wood, Lisa J.
Wang, Qing Mei
Xu, Yuming
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Fatigue is a major debilitating symptom after stroke.
The biological mechanisms underlying poststroke fatigue (PFS) are unknown.
We hypothesized that PSF is associated with an alteration in the balance between Th17 and Treg cells.
To test this hypothesis we assessed fatigue in 30 stroke survivors using the Fatigue Scale for Motor and Cognitive Functions (FSMC).
Peripheral blood was collected for assessment of Th17 and Treg cell populations and measurement of interleukin-10 (IL-10).
Participants were dichotomized into severe fatigue n=14 and low-moderate fatigue n=16 groups by K-mean cluster analysis of FSMC scores.
There were no group differences in age, gender, stroke type, stroke severity, or time since stroke.
Stroke survivors in the severe fatigue group reported greater anxiety p=0.004 and depression p=0.001 than in the low-moderate fatigue group.
The ratio of Th17 to Treg cells was significantly increased in the severe fatigue group relative to the mild-moderate fatigue group p=0.035.
Serum levels of IL-10 negatively correlated withTh17/Treg ratio (r=-0.408, p=0.025).
Our preliminary findings suggest that an imbalance in the Th17/Treg ratio is associated with the severity of PSF.
American Psychological Association (APA)
Liu, Xinjing& Kenkare, Komal& Li, Shanshan& Desai, Varsha& Wong, John& Luo, Xun…[et al.]. 2015. Increased Th17Treg Ratio in Poststroke Fatigue. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072642
Modern Language Association (MLA)
Liu, Xinjing…[et al.]. Increased Th17Treg Ratio in Poststroke Fatigue. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072642
American Medical Association (AMA)
Liu, Xinjing& Kenkare, Komal& Li, Shanshan& Desai, Varsha& Wong, John& Luo, Xun…[et al.]. Increased Th17Treg Ratio in Poststroke Fatigue. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072642