Intranasal Dexmedetomidine on Stress Hormones, Inflammatory Markers, and Postoperative Analgesia after Functional Endoscopic Sinus Surgery
Joint Authors
Tang, Chaoliang
Huang, Xiang
Kang, Fang
Chai, Xiaoqing
Wang, Song
Yin, Guobing
Wang, Hongtao
Li, Juan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
A strong ongoing intraoperative stress response can cause serious adverse reactions and affect the postoperative outcome.
This study evaluated the effect of intranasally administered dexmedetomidine (DEX) in combination with local anesthesia (LA) on the relief of stress and the inflammatory response during functional endoscopic sinus surgery (FESS).
Methods.
Sixty patients undergoing FESS were randomly allocated to receive either intranasal DEX (DEX group) or intranasal saline (Placebo group) 1 h before surgery.
Stress hormones, inflammatory markers, postoperative pain relief, hemodynamic variables, blood loss, surgical field quality, body movements, and satisfaction were assessed.
Results.
Plasma epinephrine, norepinephrine, and blood glucose levels were significantly lower in DEX group as were the plasma IL-6 and TNF-α levels (P<0.05).
The weighted areas under the curve (AUCw) of the VAS scores were also significantly lower in DEX group at 2–12 h after surgery (P<0.001).
Furthermore, hemodynamic variables, blood loss, body movements, discomfort with hemostatic stuffing, surgical field quality, and satisfaction scores of patients and surgeons were significantly better (P<0.05) in DEX group.
Conclusions.
Patients receiving intranasal DEX with LA for FESS exhibited less perioperative stress and inflammatory response as well as better postoperative comfort with hemostatic stuffing and analgesia.
American Psychological Association (APA)
Tang, Chaoliang& Huang, Xiang& Kang, Fang& Chai, Xiaoqing& Wang, Song& Yin, Guobing…[et al.]. 2015. Intranasal Dexmedetomidine on Stress Hormones, Inflammatory Markers, and Postoperative Analgesia after Functional Endoscopic Sinus Surgery. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072645
Modern Language Association (MLA)
Tang, Chaoliang…[et al.]. Intranasal Dexmedetomidine on Stress Hormones, Inflammatory Markers, and Postoperative Analgesia after Functional Endoscopic Sinus Surgery. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072645
American Medical Association (AMA)
Tang, Chaoliang& Huang, Xiang& Kang, Fang& Chai, Xiaoqing& Wang, Song& Yin, Guobing…[et al.]. Intranasal Dexmedetomidine on Stress Hormones, Inflammatory Markers, and Postoperative Analgesia after Functional Endoscopic Sinus Surgery. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072645
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072645