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Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition
Joint Authors
Garcia-Osta, Ana
Peixoto, Christina Alves
Nunes, Ana Karolina de Santana
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-03
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Phosphodiesterase type 5 inhibitors (PDE5-Is) have recently emerged as a potential therapeutic strategy for neuroinflammatory, neurodegenerative, and memory loss diseases.
Mechanistically, PDE5-Is produce an anti-inflammatory and neuroprotection effect by increasing expression of nitric oxide synthases and accumulation of cGMP and activating protein kinase G (PKG), the signaling pathway of which is thought to play an important role in the development of several neurodiseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS).
The aim of this paper was to review present knowledge of the signaling pathways that underlie the use of PDE5-Is in neuroinflammation, neurogenesis, learning, and memory.
American Psychological Association (APA)
Peixoto, Christina Alves& Nunes, Ana Karolina de Santana& Garcia-Osta, Ana. 2015. Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1072646
Modern Language Association (MLA)
Peixoto, Christina Alves…[et al.]. Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition. Mediators of Inflammation No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1072646
American Medical Association (AMA)
Peixoto, Christina Alves& Nunes, Ana Karolina de Santana& Garcia-Osta, Ana. Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1072646
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072646