Kinetic Profiles of Inflammatory Mediators in the Conjunctival Sac Fluid of Patients upon Photorefractive Keratectomy
Joint Authors
Secchiero, Paola
Tisato, Veronica
Gianesini, Sergio
Milani, Daniela
Perri, Paolo
Rimondi, Erika
Melloni, Elisabetta
Zauli, Giorgio
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Photorefractive keratectomy (PRK) represents a therapeutic option to remodel corneal stroma and to compensate refractive errors, which involves inflammatory and/or regenerative processes.
In this context, the modulation of cytokines/chemokines in the conjunctival sac fluid and their role in the maintenance of the corneal microenvironment during the healing process upon refractive procedures has not been deeply investigated.
In this study, serial samples of conjunctival sac fluid of patients ( n = 25 ) undergoing PRK were harvested before and at different time points after surgery.
The levels of 29 cytokines/chemokines/growth factors involved in inflammatory/immune processes were measured with a multiplex array system.
The results have firstly highlighted the different pattern of cytokine expression between the microenvironment at the anterior surface of the eye and the systemic circulation.
More importantly, the kinetic of modulation of cytokines/chemokines at the conjunctival level following PRK revealed that while the majority of cytokines/chemokines showed a significant decrease, MCP-1 emerged in light of its pronounced and significant increase soon after PRK and during the follow-up.
This methodological approach has highlighted the role of MCP-1 in the healing process following PRK and has shown a potential for the identification of expression/modulation of soluble factors for biomarker profiling in ocular surface diseases.
American Psychological Association (APA)
Tisato, Veronica& Perri, Paolo& Rimondi, Erika& Melloni, Elisabetta& Gianesini, Sergio& Milani, Daniela…[et al.]. 2015. Kinetic Profiles of Inflammatory Mediators in the Conjunctival Sac Fluid of Patients upon Photorefractive Keratectomy. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072651
Modern Language Association (MLA)
Tisato, Veronica…[et al.]. Kinetic Profiles of Inflammatory Mediators in the Conjunctival Sac Fluid of Patients upon Photorefractive Keratectomy. Mediators of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1072651
American Medical Association (AMA)
Tisato, Veronica& Perri, Paolo& Rimondi, Erika& Melloni, Elisabetta& Gianesini, Sergio& Milani, Daniela…[et al.]. Kinetic Profiles of Inflammatory Mediators in the Conjunctival Sac Fluid of Patients upon Photorefractive Keratectomy. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072651
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072651