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Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update
Joint Authors
O’Sullivan, Shane
Gilmer, John F.
Medina, Carlos
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-08
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Matrix metalloproteinases (MMPs) are known to be upregulated in inflammatory bowel disease (IBD) and other inflammatory conditions, but while their involvement is clear, their role in many settings has yet to be determined.
Studies of the involvement of MMPs in IBD since 2006 have revealed an array of immune and stromal cells which release the proteases in response to inflammatory cytokines and growth factors.
Through digestion of the extracellular matrix and cleavage of bioactive proteins, a huge diversity of roles have been revealed for the MMPs in IBD, where they have been shown to regulate epithelial barrier function, immune response, angiogenesis, fibrosis, and wound healing.
For this reason, MMPs have been recognised as potential biomarkers for disease activity in IBD and inhibition remains a huge area of interest.
This review describes new roles of MMPs in the pathophysiology of IBD and suggests future directions for the development of treatment strategies in this condition.
American Psychological Association (APA)
O’Sullivan, Shane& Gilmer, John F.& Medina, Carlos. 2015. Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1072665
Modern Language Association (MLA)
O’Sullivan, Shane…[et al.]. Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update. Mediators of Inflammation No. 2015 (2015), pp.1-19.
https://search.emarefa.net/detail/BIM-1072665
American Medical Association (AMA)
O’Sullivan, Shane& Gilmer, John F.& Medina, Carlos. Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1072665
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072665