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Lysosome and Cytoskeleton Pathways Are Robustly Enriched in the Blood of Septic Patients: A Meta-Analysis of Transcriptomic Data
Joint Authors
Gao, Li
Ma, Jie
Chen, Chuanxi
Barth, Andreas S.
Cheadle, Chris
Guan, Xiangdong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-30
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Background.
Sepsis is a leading cause of mortality in intensive care units worldwide.
A better understanding of the blood systems response to sepsis should expedite the identification of biomarkers for early diagnosis and therapeutic interventions.
Methods.
We analyzed microarray studies whose data is available from the GEO repository and which were performed on the whole blood of septic patients and normal controls.
Results.
We identified 6 cohorts consisting of 450 individuals (sepsis = 323, control = 127) providing genome-wide messenger RNA (mRNA) expression data.
Through meta-analysis we found the “Lysosome” and “Cytoskeleton” pathways were upregulated in human sepsis patients relative to controls, in addition to previously known signaling pathways (including MAPK, TLR).
The key regulatory genes in the “Lysosome” pathway include lysosomal acid hydrolases (e.g., protease cathepsin A, D) as well as the major (LAMP1, 2) and minor (SORT1, LAPTM4B) membrane proteins.
In contrast, pathways related to “Ribosome”, “Spliceosome” and “Cell adhesion molecules” were found to be downregulated, along with known pathways for immune dysfunction.
Overall, our study revealed distinct mRNA activation profiles and protein-protein interaction networks in blood of human sepsis.
Conclusions.
Our findings suggest that aberrant mRNA expression in the lysosome and cytoskeleton pathways may play a pivotal role in the molecular pathobiology of human sepsis.
American Psychological Association (APA)
Ma, Jie& Chen, Chuanxi& Barth, Andreas S.& Cheadle, Chris& Guan, Xiangdong& Gao, Li. 2015. Lysosome and Cytoskeleton Pathways Are Robustly Enriched in the Blood of Septic Patients: A Meta-Analysis of Transcriptomic Data. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1072676
Modern Language Association (MLA)
Ma, Jie…[et al.]. Lysosome and Cytoskeleton Pathways Are Robustly Enriched in the Blood of Septic Patients: A Meta-Analysis of Transcriptomic Data. Mediators of Inflammation No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1072676
American Medical Association (AMA)
Ma, Jie& Chen, Chuanxi& Barth, Andreas S.& Cheadle, Chris& Guan, Xiangdong& Gao, Li. Lysosome and Cytoskeleton Pathways Are Robustly Enriched in the Blood of Septic Patients: A Meta-Analysis of Transcriptomic Data. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1072676
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072676