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Antiepileptic and Antidepressive Polypharmacy in Patients with Multiple Sclerosis
Joint Authors
Beiske, Georg Anton Giæver
Holmøy, Trygve
Beiske, Antonie Giæver
Johannessen, Svein I.
Johannessen Landmark, Cecilie
Source
Multiple Sclerosis International
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Patients with multiple sclerosis (MS) are often suffering from neuropathic pain.
Antiepileptic drugs (AEDs) and tricyclic antidepressants (TCAs) are commonly used and are susceptible to be involved in drug interactions.
The aim of this retrospective study was to investigate the prevalence of use of antiepileptic and antidepressive drugs in MS patients and to discuss the theoretical potential for interactions.
Methods.
Review of the medical records from all patients treated at a dedicated MS rehabilitation centre in Norway between 2009 and 2012.
Results.
In total 1090 patients attended a rehabilitation stay during the study period.
Of these, 342 (31%; 249 females) with mean age of 53 (±10) years and EDSS 4.8 (±1.7) used at least one AED (gabapentin 12.7%, pregabalin 7.7%, clonazepam 7.8%, and carbamazepine 2.6%) or amitriptyline (9.7%).
Polypharmacy was widespread (mean 5.4 drugs) with 60% using additional CNS-active drugs with a propensity to be involved in interactions.
Age, gender, and EDSS scores did not differ significantly between those using and not using AED/amitriptyline.
Conclusion.
One-third of MS patients attending a rehabilitation stay receive AED/amitriptyline treatment.
The high prevalence of polypharmacy and use of CNS-active drugs calls for awareness of especially pharmacodynamic interactions and possible excessive adverse effects.
American Psychological Association (APA)
Beiske, Georg Anton Giæver& Holmøy, Trygve& Beiske, Antonie Giæver& Johannessen, Svein I.& Johannessen Landmark, Cecilie. 2015. Antiepileptic and Antidepressive Polypharmacy in Patients with Multiple Sclerosis. Multiple Sclerosis International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075274
Modern Language Association (MLA)
Beiske, Georg Anton Giæver…[et al.]. Antiepileptic and Antidepressive Polypharmacy in Patients with Multiple Sclerosis. Multiple Sclerosis International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1075274
American Medical Association (AMA)
Beiske, Georg Anton Giæver& Holmøy, Trygve& Beiske, Antonie Giæver& Johannessen, Svein I.& Johannessen Landmark, Cecilie. Antiepileptic and Antidepressive Polypharmacy in Patients with Multiple Sclerosis. Multiple Sclerosis International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075274
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075274